基孔肯雅热的治疗与预防:现状与展望

IF 4 4区 医学 Q1 INFECTIOUS DISEASES
Merhawi Debesai Oqbazgi
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引用次数: 1

摘要

基孔肯雅热是一种媒介传播的热带疾病,首次在坦桑尼亚爆发。这种疾病是由基孔肯雅病毒(CHIKV)引起的,这是一种属于Togaviridae科的阿尔法病毒,通过蚊子叮咬从一个人传播给另一个人。活动性疾病的特点是高烧、疼痛和关节症状。尽管这种疾病有时会使人衰弱,但很少会发展到像死亡这样的严重后果。目前还没有针对基孔肯雅病毒的特效治疗方法。临床病例管理高度依赖于提供姑息治疗,而姑息治疗反过来有望缓解症状并加速感染后的康复。控制CHIKV感染爆发的一个重要因素是预防。预防策略包括病媒控制、免疫接种和对感染患者的额外护理等举措。已经有几十项研究集中在引进针对基孔肯雅病的新药物和疫苗上。话虽如此,到目前为止,还没有一种制剂完成整个药物或疫苗的开发过程。基孔肯雅热是一种被忽视的热带疾病。尽管迄今为止还没有具体的治疗方法,但正在研究的候选疫苗和药物的数量为基孔肯雅治疗的前景提供了有希望的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment and Prevention of Chikungunya Fever: Current Status and Prospective
Chikungunya fever is a vector borne tropical disease that was first described in an outbreak in Tanzania. The disease is caused by Chikungunya virus (CHIKV), an alpha virus belonging to the family Togaviridae and which is transmitted from one person to another via the bite of mosquitoes. Active disease is characterized by high grade fever, pain and joint symptoms. Although debilitating at times, the disease seldom progresses to result in a serious outcome like death. There are no specific treatments for Chikungunya virus at the moment. Clinical case management is highly dependent on providing palliative care which in turn is expected to alleviate symptoms and accelerate recovery from the infection. An important element in the control of outbreaks of CHIKV infection is prevention. Preventive strategies involve initiatives like vector control, immunizations and extra care to patients with the infection. There have been several tens of researches focusing on the introduction of newer drugs and vaccines against Chikungunya. That being said, so far, no single agent has completed the entire drug or vaccine development process. Chikungunya fever is a neglected tropical disease. Although it has no specific treatment till date, the number of vaccine and drug candidates under study provides promising insights on the prospects on chikungunya treatment.
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来源期刊
Infectious Diseases
Infectious Diseases INFECTIOUS DISEASES-
CiteScore
8.20
自引率
1.70%
发文量
92
审稿时长
8 weeks
期刊介绍: Infectious Diseases (formerly Scandinavian Journal of Infectious Diseases) is a peer-reviewed journal publishing articles on all aspects of human infection, including pathogenesis, diagnosis, and treatment of infectious diseases, and also on medical microbiology and epidemiology
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