聚乙二醇在含疏水化合物的热敏黏附水凝胶中作为新的渗透增强剂用于阴道输送:一个离体概念研究的证明

Q3 Biochemistry, Genetics and Molecular Biology

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI:10.33263/briac134.315

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引用次数: 1

摘要

作为一种极好的替代途径，阴道途径已被广泛研究用于输送不同类型的药物。然而，通过传统的制备方法递送疏水药物是具有挑战性的。在这里，我们首次研究了将PEG作为渗透增强剂用于含有尼罗红的热敏黏附水凝胶中，作为疏水化合物的模型。采用Pluronic®F127 (P127)和Pluronic®F68 (P68)作为热敏剂，HPMC作为粘接剂。结果表明，PEG的浓度对凝胶的凝胶温度、黏附性能、pH、回收率和流变性能没有影响。最后，PEG可使尼罗红的体外渗透和滞留分别提高20倍和15倍。随着这项概念验证研究的有希望的结果，应该进行PEG在改善治疗药物阴道递送方面的应用。

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Polyethylene Glycol as New Permeation Enhancer in Thermosensitive Mucoadhesive Hydrogels Containing Hydrophobic Compound for Vaginal Delivery: An Ex Vivo Proof of Concept Study

As an excellent alternative, the vaginal route has been widely investigated to deliver different types of drugs. However, the delivery of hydrophobic drugs via conventional preparation is challenging. Here, for the first time, we investigated using PEG as a permeation enhancer in thermosensitive mucoadhesive hydrogels containing Nile red as a model of the hydrophobic compound. Pluronic® F127 (P127) and Pluronic® F68 (P68) were used as thermosensitive agents, and HPMC was used as mucoadhesive agents. The results showed that the concentration of PEG did not change the gelation temperature, mucoadhesive properties, pH, recovery, and rheological behavior of hydrogels. Finally, using PEG could improve the ex vivo permeation and retention profiles of Nile red up to 20-folds and 15-folds, respectively. Following the promising results of this proof of concept study, the application of PEG in improving the vaginal delivery of therapeutic agents should be carried out.

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来源期刊

Biointerface Research in Applied Chemistry CHEMISTRY, APPLIED-

CiteScore

4.80

自引率

0.00%

发文量

256

期刊介绍： Biointerface Research in Applied Chemistry is an international and interdisciplinary research journal that focuses on all aspects of nanoscience, bioscience and applied chemistry. Submissions are solicited in all topical areas, ranging from basic aspects of the science materials to practical applications of such materials. With 6 issues per year, the first one published on the 15th of February of 2011, Biointerface Research in Applied Chemistry is an open-access journal, making all research results freely available online. The aim is to publish original papers, short communications as well as review papers highlighting interdisciplinary research, the potential applications of the molecules and materials in the bio-field. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible.