多普勒超声在2型糖尿病患者中的应用

Q4 Medicine

Oftalmologicheskii zhurnal Pub Date : 2023-06-30 DOI:10.31288/oftalmolzh202331723

Ігор Аліфанов

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ANOVA was used for quantitative comparisons between the three groups.\n\nResults: There was a significant (р less 0.05) decrease in (a) the Vs from 71.1 +- 20.6 cm/s in the DR0 group to 59.9 +- 16.7 cm/s in the NPDR group and 47.4 +- 16.4 cm/s in the PDR group, (b) Vd from 22.1 +- 6.9 cm/s to 17.0 +- 6.6 cm/s and 12.3 +- 5.9 cm/s, respectively; and (c) TAMXV from 37.2 +- 11.3 cm/s to 31.9 +- 9.1 cm/s and 25.3 +- 9.7 cm/s, respectively, and an increase in the RI from 0.69 +- 0.06 cm/s to 0.71 +- 0.09 cm/s and 0.75 +- 0.08 cm/s, respectively, in the OA. In addition, there was a significant decrease in the Vd from 9.9 +- 5.4 cm/s in the DR0 group to 8.1 +- 3.8 cm/s in the NPDR group and 5.5 +- 3.1 cm/s in the PDR group, and an increase in the PI from 1.34 +- 0.16 cm/s to 1.46 +- 0.28 cm/s and 1.54 +- 0.24 cm/s, respectively, and in the RI from 0.71 +- 0.06 cm/s to 0.75 +- 0.07 cm/s and 0.80 +- 0.05 cm/s, respectively, in the CRA. Moreover, there was a significant decrease in the Vd from 4.3 +- 1.6 cm/s in the DR0 group to 3.2 +- 2.0 cm/s in the NPDR group and 3.1 +- 2.2 cm/s in the PDR group, and an increase in the PI from 1.32 +- 0.21 cm/s to 1.37 +- 0.24 cm/s and 1.54 +- 0.26 cm/s, respectively, and in the RI from 0.76 +- 0.04 cm/s to 0.82 +- 0.06 cm/s and 0.82 +- 0.06 cm/s, respectively, in the SPCA.\n\nConclusion: We found that the arteries examined in patients with diabetic retinopathy tended to have decreased blood flow velocities and increased resistivity and pulsatility indices, with the greatest changes observed in patients with PDR. 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引用次数: 0

摘要

目的：通过多普勒超声扫描测定2型糖尿病患者不同阶段糖尿病视网膜病变的眼血流参数。材料和方法：在这项前瞻性研究中，45例2型糖尿病患者（90眼）被分为三组，每组15例：无糖尿病视网膜病变组（DR0）、非增殖性视网膜病变（NPDR）和增殖性视网膜病（PDR）组。测定眼动脉（OA）、视网膜中央动脉（CRA）和睫状后短动脉（SPCA）的收缩血流速度（Vs）、舒张血流速度（Vd）、时间平均最大速度（TAMXV）、搏动指数（PI）和电阻率指数（RI）等多普勒指标。方差分析用于三组之间的定量比较。结果：（a）Vs从DR0组的71.1+-20.6cm/s显著降低到NPDR组的59.9+-16.7cm/s和PDR组的47.4+-16.4cm/s，（b）Vd分别从22.1+-6.9cm/s显著下降到17.0+-6.6cm/s和12.3+-5.9cm/s；和（c）TAMXV分别从37.2+-11.3cm/s增加到31.9+-9.1cm/s和25.3+-9.7cm/s，OA的RI分别从0.69+-0.06cm/s增加到0.71+-0.09cm/s和0.75+-0.08cm/s。此外，在CRA中，Vd从DR0组的9.9+-5.4 cm/s显著降低到NPDR组的8.1+-3.8 cm/s和PDR组的5.5+-3.1 cm/s，PI分别从1.34+-0.16 cm/s增加到1.46+-0.28 cm/s和1.54+-0.24 cm/s，RI分别从0.71+-0.06 cm/s增加到0.75+-0.07 cm/s和0.80+-0.05 cm/s。此外，Vd从DR0组的4.3+-1.6cm/s显著降低到NPDR组的3.2+-2.0cm/s和PDR组的3.1+-2.2cm/s，PI分别从1.32+-0.21cm/s增加到1.37+-0.24cm/s和1.54+-0.26cm/s，RI分别从0.76+-0.04cm/s增加到0.82+-0.06cm/s和0.82+-0.06cm/s，结论：我们发现糖尿病视网膜病变患者检查的动脉往往血流速度降低，电阻率和搏动指数增加，PDR患者的变化最大。此外，PDR和NPDR组之间大多数多普勒指标的平均值差异大于NPDR和DR0组之间的差异。

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Doppler ocular ultrasound in patients with type 2 diabetes mellitus

Purpose: To determine ocular blood flow parameters by Doppler ultrasound scanning in type 2 diabetic patients with different stages of diabetic retinopathy. Material and Methods: In this prospective study, forty-five patients (90 eyes) with type 2 diabetes mellitus were divided into three groups of 15 patients each: no diabetic retinopathy group (DR0), non-proliferative retinopathy (NPDR), and proliferative retinopathy (PDR) groups. Doppler indices such as systolic blood flow velocity (Vs), diastolic blood flow velocity (Vd), time-averaged maximum velocity (TAMXV), pulsatility index (PI) and resistivity index (RI) in the ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary arteries (SPCA) were determined. ANOVA was used for quantitative comparisons between the three groups. Results: There was a significant (р less 0.05) decrease in (a) the Vs from 71.1 +- 20.6 cm/s in the DR0 group to 59.9 +- 16.7 cm/s in the NPDR group and 47.4 +- 16.4 cm/s in the PDR group, (b) Vd from 22.1 +- 6.9 cm/s to 17.0 +- 6.6 cm/s and 12.3 +- 5.9 cm/s, respectively; and (c) TAMXV from 37.2 +- 11.3 cm/s to 31.9 +- 9.1 cm/s and 25.3 +- 9.7 cm/s, respectively, and an increase in the RI from 0.69 +- 0.06 cm/s to 0.71 +- 0.09 cm/s and 0.75 +- 0.08 cm/s, respectively, in the OA. In addition, there was a significant decrease in the Vd from 9.9 +- 5.4 cm/s in the DR0 group to 8.1 +- 3.8 cm/s in the NPDR group and 5.5 +- 3.1 cm/s in the PDR group, and an increase in the PI from 1.34 +- 0.16 cm/s to 1.46 +- 0.28 cm/s and 1.54 +- 0.24 cm/s, respectively, and in the RI from 0.71 +- 0.06 cm/s to 0.75 +- 0.07 cm/s and 0.80 +- 0.05 cm/s, respectively, in the CRA. Moreover, there was a significant decrease in the Vd from 4.3 +- 1.6 cm/s in the DR0 group to 3.2 +- 2.0 cm/s in the NPDR group and 3.1 +- 2.2 cm/s in the PDR group, and an increase in the PI from 1.32 +- 0.21 cm/s to 1.37 +- 0.24 cm/s and 1.54 +- 0.26 cm/s, respectively, and in the RI from 0.76 +- 0.04 cm/s to 0.82 +- 0.06 cm/s and 0.82 +- 0.06 cm/s, respectively, in the SPCA. Conclusion: We found that the arteries examined in patients with diabetic retinopathy tended to have decreased blood flow velocities and increased resistivity and pulsatility indices, with the greatest changes observed in patients with PDR. In addition, the difference in mean values of most Doppler indices between the PDR and NPDR groups was larger than that between the NPDR and DR0 groups.

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来源期刊

Oftalmologicheskii zhurnal Medicine-Ophthalmology

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： Journal of Ophthalmology (Ukraine) contains articles on eye diseases diagnosis and treatment, eye care, eye diseases prevention, history of ophthalmology, organization of eye care to population, technical equipment problems. It is committed to publishing original scientific researches and review articles on theory and practice of Ukrainian and foreign ophthalmology, cases, reviews, inventions, historical and medical reviews. It contains peer-reviews of books on ophthalmology, articles on activity of ophthalmologic societies, congresses and conferences chronicles. Journal is designed to ophthalmologists and scientific researchers in the field of vision physiology and eye diseases clinic.