IL-12在癌症中的多重作用

IF 2 Q3 ONCOLOGY

Advances in cancer biology - metastasis Pub Date : 2022-10-01 DOI:10.1016/j.adcanc.2022.100053

Um e Habiba , Mussarat Rafiq , Muhammad Babar Khawar , Bismillah Nazir , Gulfam Haider , Nadia Nazir

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引用次数: 4

摘要

白细胞介素-12是一种异二聚体细胞因子，有许多家族成员IL-23、IL-27、IL-35和最近发现的IL-39，由巨噬细胞和树突状细胞产生。IL-12是一种效应细胞因子，作为IL-12 DNA表达、Th1辅助细胞和自然杀伤细胞参与抗肿瘤和许多免疫治疗。IL-12通过激活STAT4刺激干扰素γ (INF-γ)的合成，进而分化具有T-bet转录的Th1辅助细胞，在癌症治疗中发挥重要作用。本文综述了IL-12家族作为抗肿瘤药物的作用，了解IL-12家族成员的生物学和分子机制对于设计针对不同癌症的新治疗策略至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The multifaceted role of IL-12 in cancer

Interleukin-12 is a heterodimeric cytokine having many family members IL-23, IL-27, IL-35, and recently discovered IL-39, produced by macrophages and dendritic cells. IL-12 is an effector cytokine and engages in anti-tumor and many immunotherapies as IL-12 DNA expression, Th1 helper cells, and natural killer cells. IL-12 stimulates interferon γ (INF-γ) synthesis by the activation of STAT4 which then differentiates the Th1 helper cells with the T-bet transcription, playing an important role in cancer treatment. This review focuses on the role of IL-12 family as an antitumor agent as understanding the biology and molecular mechanism of IL-12 family members is crucial for designing new therapeutic strategies against different cancers.

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来源期刊

Advances in cancer biology - metastasis Cancer Research, Oncology

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

103 days