急性吸入毒性动物试验：过去的事？

Q2 Health Professions

Applied In Vitro Toxicology Pub Date : 2018-06-01 DOI:10.1089/AIVT.2017.0037

Emilie Da Silva, J. Sørli

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引用次数: 10

摘要

摘要根据REACH（化学品注册、评估、授权和限制），以吨级生产或进口的化学品需要进行急性吸入毒性测试 ≥ 每年10吨。采用了三种OECD体内急性吸入毒性试验指南（TG 403、TG 436和TG 433）。由于动物试验在伦理、科学和经济上都有问题，因此需要欧盟和经合组织采用替代方法。介绍了一种基于肺表面活性物质功能研究的体外系统。

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Animal Testing for Acute Inhalation Toxicity: A Thing of the Past?

Abstract According to REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), testing for acute inhalation toxicity is required for chemicals manufactured or imported at tonnages ≥ 10 tons per year. Three OECD test guidelines for acute inhalation toxicity in vivo are adopted (TG 403, TG 436, and TG 433). Since animal testing is ethically, scientifically and economically questionable, adoption of alternative methods by the European Union and the OECD is needed. An in vitro system based on the study of lung surfactant function is introduced.

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来源期刊

Applied In Vitro Toxicology Health Professions-Medical Laboratory Technology

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Applied In Vitro Toxicology is a peer-reviewed journal providing the latest research on the application of alternative in vitro testing methods for predicting adverse effects in the pharmaceutical, chemical, and personal care industries. This Journal aims to address important issues facing the various chemical industries, including regulatory requirements; the reduction, refinement, and replacement of animal testing; new screening methods; evaluation of new cell and tissue models; and the most appropriate methods for assessing safety and satisfying regulatory demands. The Journal also delivers the latest views and opinions of developers of new models, end users of the models, academic laboratories that are inventing new tools, and regulatory agencies in the United States, Europe, Latin America, Australia and Asia. Applied In Vitro Toxicology is the journal that scientists involved with hazard identification and risk assessment will read to understand how new and existing in vitro methods are applied, and the questions for which these models provide answers. Applied In Vitro Toxicology coverage includes: -Applied in vitro toxicology industry standards -New technologies developed for applied in vitro toxicology -Data acquisition, cleaning, distribution, and best practices -Data protection, privacy, and policy -Business interests from research to product -The changing role of in vitro toxicology -Visualization and design principles of applied in vitro toxicology infrastructures -Physical interfaces and robotics -Opportunities around applied in vitro toxicology