Management of Oral Leukoplakia – Non-Surgical and Surgical Treatment

Aim: To evaluate the efficacy of topical retinoic acid (A-RET gel-0.025%) in homogenous leukoplakia and diode laser in non-homogenous leukoplakia patients (speckled, nodular and verrucous). Study Design: Study included total 30 patients of clinically diagnosed cases of leukoplakia; homogenous leukoplakia (n = 15) and non-homogenous leukoplakia (n = 15). Material and Method: Homogenous leukoplakia patients were given treatment of topical A-RET gel and antioxidant, while non homogenous leukoplakia patients were surgically treated by diode laser. Patients were followed up for healing after diode laser. Results: Total regression was reported in almost all cases of homogenous leukoplakia within one month, without any recurrence. Speckled leukoplakia and buccal mucosa showed faster healing as compared to other types of nonhomogenous leukoplakia with laser. Conclusion: A-RET gel and diode laser gives excellent results in homogenous and non homogenous leukoplakia cases respectively. Type of leukoplakia and lesion site plays an important role in prognosis of the lesion.