介孔二氧化硅外壳在core@shell纳米复合材料设计使抗菌作用与多种模式的作用

IF 2.5 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY
A. Pamukcu, M. Karakaplan, Şen Karaman Didem
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引用次数: 0

摘要

Core@shell结构纳米复合材料因其协同抗菌作用而受到广泛关注。在core@shell纳米结构是必要的,以确定在同一纳米结构内提供的对细菌细胞生长的抗菌协同作用core@shell结构本文介绍了一种由氧化铈核和多孔二氧化硅壳组成的新型纳米结构(CeO2@pSiO2)制备了可容纳姜黄素和凝集素的纳米复合材料,并鉴定了其抗菌协同作用。得到的球形CeO2@pSiO2纳米结构允许调节姜黄素负载量(9w/w)和凝集素(刀豆球蛋白a)涂层(15w/w)。使用针对大肠杆菌革兰氏阴性细菌菌株的最小抑制浓度测定来测试抗菌协同作用。此外,姜黄素负载和刀豆球蛋白A包被诱导细菌细胞破坏的机制CeO2@pSiO2core@shell鉴定了纳米抗生素(nanoAB)的结构及其设计成分。我们的研究结果表明,在纳米AB设计中,CeO2核心周围的介孔二氧化硅外壳有助于姜黄素和刀豆球蛋白A的调节,并促进细菌细胞运动性和细菌内外细胞膜渗透性的破坏。我们的发现有力地表明,在具有CeO2核的纳米颗粒周围的介孔二氧化硅壳具有提供协同抗菌处理和通过不同作用机制攻击细菌细胞的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mesoporous silica shell in a core@shell nanocomposite design enables antibacterial action with multiple modes of action
Core@shell structured nanocomposites have received significant attention for their synergistic mode of antibacterial action. Identification of the accommodated unit’s function in the core@shell nanostructure is necessary in order to determine whether antibacterial synergism against bacterial cell growth that is provided within the same core@shell structure. Herein, a novel nanostructure(s) composed of a cerium oxide core and a porous silica shell (CeO2@pSiO2) accomodating curcumin and lectin was prepared, and the antibacterial synergism provided by the nanocomposite was identified. The resulting spherical-shaped CeO2@pSiO2 nanostructure allowed accommodation of curcumin loading (9 w/w%) and a lectin (concanavalin A) coating (15 w/w%). The antibacterial synergism was tested using a minimal inhibitory concentration assay against an Escherichia coli Gram-negative bacterial strain. Furthermore, the mechanisms of bacterial cell disruption induced by the curcumin-loaded and concanavalin A-coated CeO2@pSiO2 core@shell structure, namely the nanoantibiotic (nano-AB) and its design components, were identified. Our findings reveal that the mesoporous silica shell around the CeO2 core within the nano-AB design aids the accommodation of curcumin and concanavalin A and promotes destruction of bacterial cell motility and the permeability of the inner and outer bacterial cell membranes. Our findings strongly indicate the promising potential of a mesoporous silica shell around nanoparticles with a CeO2 core to provide synergistic antibacterial treatment and attack bacterial cells by different mechanisms of action.
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来源期刊
Nano Futures
Nano Futures Chemistry-General Chemistry
CiteScore
4.30
自引率
0.00%
发文量
35
期刊介绍: Nano Futures mission is to reflect the diverse and multidisciplinary field of nanoscience and nanotechnology that now brings together researchers from across physics, chemistry, biomedicine, materials science, engineering and industry.
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