美国老年人的退休和表观遗传年龄加速

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-07-15 DOI:10.1007/s40750-023-00221-2

Aniruddha Das

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引用次数: 1

摘要

目的本研究调查了老年男性和女性的退休状况与其生理年龄加速的关系，以及抑郁症状对这些联系的中介作用。方法数据来自2010-2016年的健康与退休研究，该研究在全国范围内代表了美国老年人。年龄加速是通过新的表观遗传学测量来表征的。双稳健估计用于建立基线联系，并使用异质性治疗效果模型来检查因退休倾向增加而产生的效果变化。中介分析是通过最近开发的结构嵌套均值模型的残差回归（RWR）方法进行的。结果经过治疗评估6年后，基线退休的女性比完全就业的女性衰老更快。退休男性随后的抑郁症状较低，稀疏的结果也支持他们衰老较慢。无论男女，协会都没有随着退休倾向的增加而发生显著变化。结论研究结果为退休的性别特异性衰老效应提供了新的证据。潜在的生活方式机制尚未探索。讨论了对个人和政策的影响。

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Retirement and Epigenetic age Acceleration Among Older U.S. Adults

Purpose

This study examined associations of older men’s and women’s retired status with their biological age acceleration, and mediation of these linkages by depressive symptoms.

Methods

Data were from the 2010–2016 waves of the Health and Retirement Study, nationally representative of older U.S. adults. Age acceleration was proxied through newly available epigenetic measures. Doubly robust estimation was used to establish baseline linkages, and heterogenous treatment effect models to examine variations in effects by one’s increasing propensity to be retired. Mediation analysis was through a recently developed regression-with-residuals (RWR) approach for structural nested mean models.

Results

Six years after treatment assessment, women retired at baseline showed faster aging than those fully employed. Retired men’s subsequent depressive symptoms were lower, with sparse results also supporting their slower senescence. Associations did not significantly change with increasing propensity for being retired, for either gender.

Conclusion

Results provide novel evidence for retirement’s gender-specific senescence effects. Potential lifestyle mechanisms remain unexplored. Individual and policy implications are discussed.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.