二氢槲皮素、1-芳基四氢异喹啉及其偶联物对大鼠肝线粒体膜功能的影响

Q4 Agricultural and Biological Sciences

Nova Biotechnologica et Chimica Pub Date : 2023-07-21 DOI:10.34135/nbc.1414

Z. Ernazarov, M. Pozilov, M. Asrarov, Sherzod N. Zhurakulov

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引用次数: 0

摘要

摘要在本研究论文中，黄酮类化合物二氢槲皮素，1-（2´-溴-4´，5´-二甲氧基苯基）-6,7-二甲基-1，2，3，4-四氢异喹啉（F-18）和2-（3，4-二羟基苯基）-6-（1-（2’-溴-4’，5´-二甲氧基苯基）/6,7-二乙氧基-3,4-二氢异喹啉-2（1N）-il）甲基-3。在体外实验中研究了5，7-三idroxychroman-4-on（DHQ-11）偶联物对大鼠肝脏线粒体钙巨通道和Fe2+/柠檬酸盐诱导的脂质过氧化（LPO）的影响。实验中使用了体重180-200克的白色雄性大鼠。研究发现，DHQ-11偶联物对Fe2+/柠檬酸盐诱导的大鼠肝线粒体对钙巨通道和脂质过氧化具有抑制作用。DHQ-11偶联物对肝线粒体钙巨通道和线粒体膜脂质过氧化的抑制作用被鉴定为对二氢槲皮素和F-18异喹啉生物碱具有活性。

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Effects of dihydroquercetin, 1-aryltetrahydroisoquinoline, and conjugate on the functional condition mitochondrial membrane of the rat liver

Abstract In the current research paper, the flavonoid dihydroquercetin, 1-(2´-bromine-4´,5´-dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) and 2-(3,4-dihydroxyphenyl)-6-(1-(2´-bromine-4´, 5´-dimethoxyphenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2 (1N)-il) methyl-3. The effects of 5,7-trigidroxychroman-4-on (DHQ-11) conjugate on rat liver mitochondrial calcium megachannels and on lipid peroxidation (LPO) induced using Fe2+/citrate were investigated in vitro experiments. White male rats weighing 180-200 grams were used in the experiments. It was found that the DHQ-11 conjugate was identified to have an inhibitory effect on rat liver mitochondria to calcium megachannels and peroxidation of lipids induced by Fe2+/citrate. The inhibitory properties of DHQ-11 conjugate on hepatic mitochondrial calcium megachannels and mitochondrial membrane lipid peroxidation were identified as active against dihydroquercetin and the F-18 isoquinoline alkaloid.

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来源期刊

Nova Biotechnologica et Chimica Agricultural and Biological Sciences-Food Science

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

24 weeks