台湾循环死亡后捐献器官移植的发展与结果

Q4 Medicine
Yueh-Ping Liu , Chi-Shin Tseng , Yang-Jen Chiang , Jeff S. Chueh , Jui-Yuan Hsueh
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引用次数: 1

摘要

背景:由于移植器官的持续短缺,增加供体库势在必行。因此,台湾于2017年重新引入循环死亡后器官捐献(DCD),并成为肾脏和肝脏移植的合法来源。我们的目的是报告台湾DCD供体器官移植的初步结果。方法48例DCD供体及106例移植资料均来自台湾器官登记共享中心。2018年1月5日至2021年9月24日进行肾脏和肝脏移植。Kaplan-Meier法测定的主要终点为受体生存期和移植物生存期。结果2017 - 2021年,DCD献血者占全部死亡献血者的9.6%(48/501)。DCD肾移植的受者3个月、1年和3年生存率分别为99%、94%和94%;DCD肝移植的比例分别为86% 76%和76%。移植肾3个月和3年生存率(剔除死亡)分别达到95%和94%;而肝移植存活率(剔除死亡)分别达到95%和89%。结论DCD供体在肾、肝移植中均表现出满意的移植和受体存活率。来自潜在DCD供者的肾脏和肝脏移植都应该提倡,因为其结果与来自脑死亡的已故供者的器官相当。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The development and outcomes of organ transplantation from donation after circulatory death in Taiwan

Background

It is imperative to increase the donor pool due to a persistent shortfall of organs for transplantation. Therefore, organ donation after circulatory death (DCD) was reintroduced in Taiwan in 2017, and has become a rightful source for kidney and liver transplantation. We aim to report the preliminary outcomes of organ transplantation from DCD donors in Taiwan.

Methods

All data of 48 DCD donors and consecutively 106 grafts were obtained from the registry of Taiwan Organ Registry and Sharing Center. Kidney and liver transplantations were performed between Jan 5th, 2018 and Sep 24th, 2021. The primary endpoints were recipient survival and graft survival by using Kaplan-Meier method.

Results

Overall, DCD donors accounted for 9.6% (48/501) of all deceased donors in Taiwan from 2017 to 2021. The recipient survival for 3-month, 1-year, and 3-year were 99, 94, and 94% for DCD kidney transplants; 86, 76 and 76% for DCD liver transplants. The 3-month and three-year kidney graft survival (censored for death) reached 95% and 94%, respectively; while liver graft survival (censored for death) reached 95% and 89%, respectively.

Conclusions

Transplantations from DCD donors showed satisfactory graft and recipient survivals in both kidney and liver transplants. Both kidney and liver transplantation from potential DCD donors should be advocated for its comparable outcomes to organs from brain-dead deceased donors.

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来源期刊
Transplantation Reports
Transplantation Reports Medicine-Transplantation
CiteScore
0.60
自引率
0.00%
发文量
24
审稿时长
101 days
期刊介绍: To provide to national and regional audiences experiences unique to them or confirming of broader concepts originating in large controlled trials. All aspects of organ, tissue and cell transplantation clinically and experimentally. Transplantation Reports will provide in-depth representation of emerging preclinical, impactful and clinical experiences. -Original basic or clinical science articles that represent initial limited experiences as preliminary reports. -Clinical trials of therapies previously well documented in large trials but now tested in limited, special, ethnic or clinically unique patient populations. -Case studies that confirm prior reports but have occurred in patients displaying unique clinical characteristics such as ethnicities or rarely associated co-morbidities. Transplantation Reports offers these benefits: -Fast and fair peer review -Rapid, article-based publication -Unrivalled visibility and exposure for your research -Immediate, free and permanent access to your paper on Science Direct -Immediately citable using the article DOI
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