Potency of Cape Gooseberry (Physalis Peruviana) Juice in Improving Antioxidant and Adiponectin Level of High Fat Diet Streptozotocin Rat Model

Abstract Background and aims: Quercetin belonging flavonoid has a role to improve diabetic condition. Research aimed to examine and to compare Cape Gooseberry (CG) juice and quercetin supplement on Total Antioxidant Capacity (TAC) and adiponectin level of high fat diet-Streptozotocin (HFD-STZ) induced rat. Material and method: CG juice 5 ml/kg/d (X1) and 25 ml/kg/d (X2) groups; and quercetin supplement 2.2 mg/kg/d (X3) and 30 mg/kg/d (X4) groups were compared with both of positive (K+) and negative (K-) control. Treatments were given by orally gavage for 28 days to 36 Wistar rats which each group consisted of 6 rats. TAC and adiponectin level were measured by ABTS and ELISA method respectively. Results: There was significantly increase of TAC in treatment groups compared with K(+) (p<0.05). X2 had TAC level significantly higher than X1 (p=0.025). Moreover, adiponectin level of treatment groups were significantly higher than K(+) (p<0.05). Furthermore, X2 had adiponectin level significantly higher than X3 (p<0.001). Conclusion: CG juice 25 ml/kg/d presented better effect than CG juice 5 ml/kg/d, although quercetin 30 mg/kg/d showed the best effects toward both of TAC and adiponectin.