糖源性手性池合成抗病毒药物的研究进展

IF 1.2 4区化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Carbohydrate Chemistry Pub Date : 2022-01-01 DOI:10.1080/07328303.2023.2189473

Anjali Sharma , Smritilekha Bera , Dhananjoy Mondal

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引用次数: 0

摘要

碳水化合物是最丰富的天然产物，是生物细胞表面的主要成分。由于它们的多个手性中心和羟基的存在，它们是各种天然产物和有机合成的有用基石。最近爆发的COVID-19和其他危及生命的病毒感染要求开发强效抗病毒药物。本文综述了以d -葡萄糖、d -甘露糖、d -木糖、n -乙酰- d -葡萄糖胺、d -葡萄糖酸内酯等不同单糖为原料，如抗流感药物瑞德西韦、达菲、扎那米韦等，合成治疗流感、HIV、疱疹、肝炎等疾病的抗病毒药物。下载:下载高分辨率图片(247KB)下载:下载全尺寸图片

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Advances in the synthesis of antiviral agents from carbohydrate-derived chiral pools

Carbohydrates are the most abundant natural products and a major component on the cell surface of living beings. They are useful building blocks of various natural products and organic synthesis due to their presence of multiple chiral centers and hydroxy groups. The recent outbreak of COVID-19 and other life-threatening viral infections necessitates the development of potent antiviral drugs. In this review, we focused on the synthesis of antiviral drugs to treat influenza, HIV, herpes, hepatitis, and other diseases, from different monosaccharides such as D-glucose, D-mannose, D-xylose, N-acetyl-D-glucosamine, D-gluconolactone, etc., such as anti-influenza drugs remdesivir, Tamiflu, zanamivir, and so on.

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来源期刊

Journal of Carbohydrate Chemistry 化学-生化与分子生物学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Carbohydrate Chemistry serves as an international forum for research advances involving the chemistry and biology of carbohydrates. The following aspects are considered to fall within the scope of this journal: -novel synthetic methods involving carbohydrates, oligosaccharides, and glycoconjugates- the use of chemical methods to address aspects of glycobiology- spectroscopic and crystallographic structure studies of carbohydrates- computational and molecular modeling studies- physicochemical studies involving carbohydrates and the chemistry and biochemistry of carbohydrate polymers.