Maia Drasin , Gregory Rumore , Elizabeth Suh-Burgmann
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引用次数: 0
摘要
CA 19-9(碳水化合物抗原19-9)被用作肝胆癌的生物标志物,通常被认为对妇科癌症的评估没有帮助。子宫内膜异位症相关的癌症是妇科癌症的一个子集,其中恶性肿瘤与子宫内膜异位症相邻,在妇科道内或外。我们描述了一例CA 19-9水平为49,469 U/mL的女性,她随后被发现患有两种并发但单独的原发性子宫内膜异位症相关癌症,涉及卵巢和小肠。虽然缺乏关于CA 19-9与子宫内膜异位症相关恶性肿瘤之间关系的数据,但众所周知,子宫内膜异位症与高水平的炎症有关,而炎症反过来又与较高的CA 19-9水平有关。在子宫内膜异位症相关的恶性肿瘤累及腹膜的情况下,炎症反应和对CA 19-9水平的影响可能特别明显。所描述的病例提示,当CA 19-9水平极高且无明显肝胆疾病的女性怀疑患有癌症时,可能需要考虑子宫内膜异位症相关的恶性肿瘤。
Extreme elevation of CA19-9 in patient with endometriosis-associated cancer: A brief report and review of the literature
CA 19-9 (carbohydrate antigen 19-9) is used as a biomarker for hepatobiliary cancer and is generally not considered helpful in the evaluation of gynecologic cancer. Endometriosis-associated cancers are a subset of gynecologic cancers in which malignancy is found adjacent to endometriosis either within or outside the gynecologic tract. We describe a case of a woman who presented with a CA 19-9 level of 49,469 U/mL who was subsequently found to have two concurrent but separate primary endometriosis-associated cancers involving the ovary and small intestine. Although data regarding the association between CA 19-9 and endometriosis-associated malignancy is lacking, endometriosis is known to be associated with high levels of inflammation which in turn has been associated with higher CA 19-9 levels. The inflammatory response and effect on CA 19-9 levels may be particularly pronounced in cases where endometriosis-associated malignancy involves the peritoneum. The case described suggests that when cancer is suspected in a woman with an extremely high level of CA 19-9 and no apparent hepatobiliary disease, an endometriosis-associated malignancy may be a consideration.