CONNECTION OF VITAMIN D WITH MARKERS OF REPRODUCTIVE FUNCTION IN PATIENTS WITH WITH POLYCYSTIC OVARY SYNDROME

Objective. To investigate the relationship between vitamin D and markers of reproductive function in women with polycystic ovary syndrome (PCOS) and to assess of their changes with cholecalciferol.Materials and methods. Thirty patients with PCOS and 20 healthy women with vitamin D deficiency, who similar for the age and body weight, were examined. Vitamin D, antimullerian hormone (AMH), number of antral follicles, follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), estradiol (E2), sex hormone-binding globulin (SHBG), ovarian ultrasound parameters before and after 12 weeks of cholecalciferol therapy at a dose of 4000 IU daily were determined.Results. Before treatment, was not found association between vitamin D and AMG and the number of antral follicles in both groups. In patients with PCOS was found a negative relationship between vitamin D and T (r = – 0.579; P < 0.001), free androgen index (r = – 503; Р < 0.01), LH/FSH (r = – 0.591, P < 0.001), T/E2 (r = – 0.603; P < 0.001) and positive correlation with SHBG (r = 0.611; P < 0.001), which indicates the role of vitamin D deficiency in the formation of hyperandrogenemia. The therapy of cholecalciferol did not affect the level of AMН, at the same time, was accompanied by changes in gonadotropin secretion and their ratio, reduction of hyperandrogenemia and positive dynamics of folliculogenesis.Conclusion. We believe that the appointment of vitamin D in patients with PCOS is promising, as it has a positive effect on indicators that reflect the state of reproductive function.