UGT基因的计算机分析作为初步数据:(A- review)

IF 0.6 Q4 CHEMISTRY, MULTIDISCIPLINARY

Oriental Journal Of Chemistry Pub Date : 2023-08-30 DOI:10.13005/ojc/390402

U. Adiga

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引用次数: 3

摘要

反复的无端发作是癫痫的一个特征，癫痫是一种慢性神经系统疾病，由皮层神经元传导方式的瞬间变化引起。癫痫患者已经接受了20多种抗癫痫药物(aed)的治疗，以控制癫痫发作，但其中三分之一的患者对这些药物产生了耐药性。癫痫的药理学治疗经常涉及治疗性药物监测(TDM)，尽管各种抗癫痫药的血浆水平并不总是与药物的剂量和/或治疗或有害作用很好地对应。参与这些药物代谢的许多酶的遗传多态性可能是造成这种情况的原因。该研究的目的是利用生物信息学方法检测UGT1A6和UGT2B7基因多态性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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In silico Analysis of UGT Gene as A Preliminary Data: (A-Review)

Recurrent unprovoked seizures are a hallmark of epilepsy, a chronic neurological condition caused by momentary changes in the way cortical neurons conduct electricity. Epilepsy patients have been treated with more than 20 anti-epileptic medicines (AEDs) to control their seizures, but one-third of them are resistant to the drugs. The pharmacological treatment of epilepsy frequently involves therapeutic drug monitoring (TDM), although the plasma levels of various AEDs do not always correspond well with the doses and/or the therapeutic or harmful effects of the medications. The genetic polymorphisms of numerous enzymes involved in the metabolism of these medications may be to blame for this. The study's goal was to examine UGT1A6 and UGT2B7 gene polymorphisms using bioinformatics methods.

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来源期刊

Oriental Journal Of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

自引率

20.00%

发文量

172

期刊介绍： Oriental Journal of Chemistry was started in 1985 with the aim to promote chemistry research. The journal consists of articles which are rigorously peer-reviewed. The journal was indexed in Emerging Science citation index in 2016. The Editorial board member consists of eminent international scientist in all fields of Chemistry. Details of each member and their contact information is mentioned in website. The journal has thorough ethics policies and uses plagiarism detection software(ithenticate) to screen each submission. The journal has recently partnered with publons as a part of making our reviews more transparent. The journal has recently incorporated PlumX for article level matrix. The journal is promoting research on all social and academic platforms mentioned in PlumX guidelines. The journal uses google maps to improve on the geographical distribution of Editorial board members as well as authors.