3D打印关节软骨组织工程生物可吸收支架:纯聚己内酯(PCL)与聚乳酸-b-乙二醇(PLA-PEG)嵌段共聚物的比较研究

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL

Biomedical materials Pub Date : 2022-06-14 DOI:10.1088/1748-605X/ac78b7

Uzuri Urtaza, O. Guaresti, Izar Gorroñogoitia, Ana Zubiarrain-Laserna, Emma Muiños‐López, Froilán Granero-Moltó, JM Lamo de Espinosa, T. López-Martínez, M. Mazo, F. Prósper, A. Zaldua, J. Anakabe

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引用次数: 2

摘要

这项工作确定并描述了软骨组织工程(CTE)的不同材料-支架几何组合。先前报道的可能有趣的支架几何形状是使用生物可吸收的聚己内酯和聚(丙交酯-乙乙烯)嵌段共聚物进行调整和打印的。这两种聚合物的医用级都是在ISO 7级洁净室中使用熔丝制造技术进行3D打印的。然后对得到的支架进行光学、机械和生物学测试。结果表明，一些材料-支架的几何组合具有优异的细胞活力和增强细胞软骨性质的潜力，因此表明它们适用于CTE应用。

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3D printed bioresorbable scaffolds for articular cartilage tissue engineering: a comparative study between neat polycaprolactone (PCL) and poly(lactide-b-ethylene glycol) (PLA-PEG) block copolymer

This work identifies and describes different material-scaffold geometry combinations for cartilage tissue engineering (CTE). Previously reported potentially interesting scaffold geometries were tuned and printed using bioresorbable polycaprolactone and poly(lactide-b-ethylene) block copolymer. Medical grades of both polymers were 3D printed with fused filament fabrication technology within an ISO 7 classified cleanroom. Resulting scaffolds were then optically, mechanically and biologically tested. Results indicated that a few material-scaffold geometry combinations present potential for excellent cell viability as well as for an enhance of the chondrogenic properties of the cells, hence suggesting their suitability for CTE applications.

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来源期刊

Biomedical materials 工程技术-材料科学：生物材料

CiteScore

6.70

自引率

7.50%

发文量

294

审稿时长

3 months

期刊介绍： The goal of the journal is to publish original research findings and critical reviews that contribute to our knowledge about the composition, properties, and performance of materials for all applications relevant to human healthcare. Typical areas of interest include (but are not limited to): -Synthesis/characterization of biomedical materials- Nature-inspired synthesis/biomineralization of biomedical materials- In vitro/in vivo performance of biomedical materials- Biofabrication technologies/applications: 3D bioprinting, bioink development, bioassembly & biopatterning- Microfluidic systems (including disease models): fabrication, testing & translational applications- Tissue engineering/regenerative medicine- Interaction of molecules/cells with materials- Effects of biomaterials on stem cell behaviour- Growth factors/genes/cells incorporated into biomedical materials- Biophysical cues/biocompatibility pathways in biomedical materials performance- Clinical applications of biomedical materials for cell therapies in disease (cancer etc)- Nanomedicine, nanotoxicology and nanopathology- Pharmacokinetic considerations in drug delivery systems- Risks of contrast media in imaging systems- Biosafety aspects of gene delivery agents- Preclinical and clinical performance of implantable biomedical materials- Translational and regulatory matters