V. Pavlenko, AI Kaida, VN Klinkov, A. Mikhailova, LS Orekhova, AA Portugalskaya
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The study involved children 4–7 years old with ASD (n = 26) and their normally developing peers without the condition (n = 37). Although in most cases, HB was more pronounced in the group of normally developing children, the differences between the groups are significant only for altruistic HP (p < 0.01), and for the situation requiring complex altruistic and emotional HP it approaches significance (p = 0.09). Evaluation of the mu rhythm reactivity indices showed that the tasks invoking complex altruistic and emotional HB bring this indicator down significantly in children with ASD compared to the group of normally developing participants, as shown by the central leads of the left and right hemispheres and the parietal lead of the right hemisphere (C3: p = 0.02 ; C4: p = 0.03; P4: p = 0.03). It is assumed that the detected features stem from the impaired functioning of the MNS and the downstream regulation to the MNS from prefrontal cortex and other areas of the neocortex. 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引用次数: 0
摘要
镜像神经元系统(MNS)在自闭症谱系障碍(ASD)儿童违反社会行为中可能发挥的作用是目前医学界讨论的主题之一。众所周知,MNS可以塑造对他人情绪的感知,以及对他人行为的理解和模仿。脑电图中的Mu节律不同步被认为是MNS激活的标志。本研究的目的是确定ASD学龄前儿童在需要工具性、情绪性和利他性帮助行为(HB)的情况下,在个体确定的频率范围内的脑电图mu节律的反应性特征。该研究涉及4-7岁患有ASD的儿童(26名)和他们正常发育的同龄人(37名)。虽然在大多数情况下,HB在正常发育儿童组中更为明显,但只有在利他性HP组中差异显著(p < 0.01),在需要复杂利他性和情绪性HP的情况下差异接近显著(p = 0.09)。节律反应性指标的评估表明,与正常发育组相比,复杂利他性和情绪性HB诱发任务显著降低了ASD儿童的该指标,左、右半球中央导联和右半球顶叶导联显示(C3: p = 0.02;C4: p = 0.03;P4: p = 0.03)。假设检测到的特征源于MNS功能受损以及前额叶皮层和其他新皮层区域对MNS的下游调节。所获得的数据可用于开发ASD儿童的脑电图生物反馈训练方案。
Features of reactivity of the EEG mu rhythm in children with autism spectrum disorders in helping behavior situations
One of the subjects being discussed by the professional community currently is the role possibly played by the mirror neuron system (MNS) in the violation of social behavior of children with autism spectrum disorders (ASD). The MNS is known to shape the perception of emotions of others and understanding and imitation of their actions. Mu rhythm desynchronization in EEG is considered to be the indicator of the MNS activation. The purpose of this study was to identify the features of reactivity of the EEG mu rhythm within an individually determined frequency range in preschoolers with ASD in situations requiring instrumental, emotional and altruistic helping behavior (HB). The study involved children 4–7 years old with ASD (n = 26) and their normally developing peers without the condition (n = 37). Although in most cases, HB was more pronounced in the group of normally developing children, the differences between the groups are significant only for altruistic HP (p < 0.01), and for the situation requiring complex altruistic and emotional HP it approaches significance (p = 0.09). Evaluation of the mu rhythm reactivity indices showed that the tasks invoking complex altruistic and emotional HB bring this indicator down significantly in children with ASD compared to the group of normally developing participants, as shown by the central leads of the left and right hemispheres and the parietal lead of the right hemisphere (C3: p = 0.02 ; C4: p = 0.03; P4: p = 0.03). It is assumed that the detected features stem from the impaired functioning of the MNS and the downstream regulation to the MNS from prefrontal cortex and other areas of the neocortex. The data obtained can be used in development of EEG biofeedback training protocols for children with ASD.
期刊介绍:
Bulletin of Russian State Medical University (Bulletin of RSMU, ISSN Print 2500–1094, ISSN Online 2542–1204) is a peer-reviewed medical journal of Pirogov Russian National Research Medical University (Moscow, Russia). The original language of the journal is Russian (Vestnik Rossiyskogo Gosudarstvennogo Meditsinskogo Universiteta, Vestnik RGMU, ISSN Print 2070–7320, ISSN Online 2070–7339). Founded in 1994, it is issued once every two months publishing articles on clinical medicine and medical and biological sciences, first of all oncology, neurobiology, allergy and immunology, medical genetics, medical microbiology and infectious diseases. Every issue is thematic. Deadlines for manuscript submission are announced in advance. The number of publications on topics in spite of the issue topic is limited. The journal accepts only original articles submitted by their authors, including articles that present methods and techniques, clinical cases and opinions. Authors must guarantee that their work has not been previously published elsewhere in whole or in part and in other languages and is not under consideration by another scientific journal. The journal publishes only one review per issue; the review is ordered by the editors.