{"title":"结合机器学习的工程方法在患者特异性神经导管的生物制造中的应用——综述","authors":"Devara Venkata Krishna, Mamilla Ravi Sankar","doi":"10.1016/j.bprint.2023.e00264","DOIUrl":null,"url":null,"abstract":"<div><p>Nervous system<span><span> plays a dynamic role in communicating information from the brain to body parts through central and peripheral nerves. Significant destruction to the nerve system instigates loss of sensor and motor functions. The regeneration of such damaged nerve is essential for retaining its functionality. It requires the scaffold, which acts as an aqueduct between the distal and </span>proximal ends<span> during regeneration. The present review is mainly concerned with the design aspects of fabricating nerve guidance conduits (NGCs) for rectifying injured peripheral nerves using advanced materials<span><span><span> and manufacturing methods. A detailed review is presented on the biological and structural properties of nerve conduits. The different design features of the NGCs are elaborated concerning biocompatibility, </span>cell adhesion, and proliferation enhancement. The various biocompatible materials and additives used for fabricating nerve conduits are elaborately discussed. The application of machine learning is elaborated at different stages in developing the NGCs. In addition, challenges and futuristic aspects for improving scaffold properties in repairing and regenerating </span>peripheral nerve injuries are explicated.</span></span></span></p></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Engineered approach coupled with machine learning in biofabrication of patient-specific nerve guide conduits - Review\",\"authors\":\"Devara Venkata Krishna, Mamilla Ravi Sankar\",\"doi\":\"10.1016/j.bprint.2023.e00264\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Nervous system<span><span> plays a dynamic role in communicating information from the brain to body parts through central and peripheral nerves. Significant destruction to the nerve system instigates loss of sensor and motor functions. The regeneration of such damaged nerve is essential for retaining its functionality. It requires the scaffold, which acts as an aqueduct between the distal and </span>proximal ends<span> during regeneration. The present review is mainly concerned with the design aspects of fabricating nerve guidance conduits (NGCs) for rectifying injured peripheral nerves using advanced materials<span><span><span> and manufacturing methods. A detailed review is presented on the biological and structural properties of nerve conduits. The different design features of the NGCs are elaborated concerning biocompatibility, </span>cell adhesion, and proliferation enhancement. The various biocompatible materials and additives used for fabricating nerve conduits are elaborately discussed. The application of machine learning is elaborated at different stages in developing the NGCs. In addition, challenges and futuristic aspects for improving scaffold properties in repairing and regenerating </span>peripheral nerve injuries are explicated.</span></span></span></p></div>\",\"PeriodicalId\":37770,\"journal\":{\"name\":\"Bioprinting\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioprinting\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405886623000076\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Computer Science\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886623000076","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}
Engineered approach coupled with machine learning in biofabrication of patient-specific nerve guide conduits - Review
Nervous system plays a dynamic role in communicating information from the brain to body parts through central and peripheral nerves. Significant destruction to the nerve system instigates loss of sensor and motor functions. The regeneration of such damaged nerve is essential for retaining its functionality. It requires the scaffold, which acts as an aqueduct between the distal and proximal ends during regeneration. The present review is mainly concerned with the design aspects of fabricating nerve guidance conduits (NGCs) for rectifying injured peripheral nerves using advanced materials and manufacturing methods. A detailed review is presented on the biological and structural properties of nerve conduits. The different design features of the NGCs are elaborated concerning biocompatibility, cell adhesion, and proliferation enhancement. The various biocompatible materials and additives used for fabricating nerve conduits are elaborately discussed. The application of machine learning is elaborated at different stages in developing the NGCs. In addition, challenges and futuristic aspects for improving scaffold properties in repairing and regenerating peripheral nerve injuries are explicated.
期刊介绍:
Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.