紫饮降活宁心汤联合脱氢表雄酮、铁素治疗绝经期症状的疗效观察

IF 2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
Lin Jing , Zhu Jun , Tian Fubo , Chen Lanting , Zhang Yang , Wang Yan , Wang Mingyan , Hans-Jürgen Gober , Li Dajin , Wang Ling
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引用次数: 4

摘要

目的观察紫饮降活宁心汤联合脱氢表雄酮(DHEA)和更年期激素治疗(MHT)对中医认为阴虚火旺型绝经期症状的疗效。方法将180名年龄在40 ~ 60岁的绝经后妇女分为4组,分别接受激素、激素联合ZYJHNXD、激素联合脱氢表雄酮、激素联合ZYJHNXD和脱氢表雄酮治疗,疗程3个月。常见的基于问卷的测量工具包括改良的Kupperman指数(MKI)、汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)。分别于治疗前和治疗后3个月测定促卵泡激素(FSH)、促黄体生成素(LH)、雌二醇(E2)、5-羟基吲哚-3-乙酸(5-HIAA)、去甲肾上腺素(NE)、多巴胺(DA)、骨密度(BMD)和睡眠质量。结果4组患者MKI、HAMA、HAMD评分及FSH、LH水平均显著降低(P <0.05), E2、5-HIAA、NE、DA水平明显升高(P <0.05)。ZYJHNXD和DHEA联合铁素组在保持骨密度、改善总睡眠时间和夜间睡眠时间方面优于其他三组。结论zyjhnxd联合DHEA联合MHT治疗绝经后妇女在控制绝经期症状、恢复激素水平、预防骨骼疏松或骨质疏松、改善睡眠质量等方面效果良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Ziyin Jianghuo Ningxin decoction plus dehydroepiandrosterone and femoston in treatment of patients with menopausal symptoms

OBJECTIVE

To determine the therapeutic effect of Ziyin Jianghuo Ningxin Decoction (ZYJHNXD) plus dehydroepiandrosterone (DHEA) and menopausal hormone therapy (MHT) in patients suffering from menopausal symptoms identified as, in terms of Traditional Chinese Medicine, symptom pattern of Yin deficiency with hyperactive fire.

METHODS

Totally 180 postmenopausal women aged 40 to 60 years were assigned into four groups and accepted femoston, femoston with ZYJHNXD, femoston with DHEA, femoston with ZYJHNXD and DHEA therapies, respectively, for three months. Common questionnaire-based measure instruments included modified Kupperman index (MKI), Hamilton Rating Scale for Anxiety (HAMA), and Hamilton Rating Scale for Depression (HAMD). Follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), 5-hydroxyindole-3-acetic acid (5-HIAA), norepinephrine (NE), dopamine (DA), bone mineral density (BMD), and sleep quality were evaluated before and three months after the treatments.

RESULTS

In all four groups, the scores of MKI, HAMA, HAMD and the levels of FSH, LH decreased significantly (P < 0.05) after the treatment, while the levels of E2, 5-HIAA, NE, and DA showed obvious elevation (P < 0.05). The group receiving ZYJHNXD and DHEA combined with femoston had superiority in the preservation of bone mineral density and improvement of total sleep time and nighttime sleep time over the other three groups.

CONCLUSION

ZYJHNXD and DHEA combined with MHT therapy have a favorable outcome in managing menopausal symptoms, restoring hormone levels, preventing skeletal rarefaction or osteoporosis, and improving sleep quality for postmenopausal women.

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来源期刊
Journal of Traditional Chinese Medicine
Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
2.40
自引率
3.80%
发文量
32269
审稿时长
2 months
期刊介绍: Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.
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