{"title":"感染性心内膜炎预后预测因素的回顾性研究","authors":"Y. Yiu","doi":"10.55503/2790-6744.1070","DOIUrl":null,"url":null,"abstract":"Background : Infective endocarditis (IE) is associated with signi fi cant mortality and morbidity. This study aims to up-date the epidemiology of IE and to identify predictors of adverse outcome in the Chinese population in Hong Kong. Methods : This was a single-centre retrospective study of patients diagnosed with IE in Princess Margaret Hospital in Hong Kong during 2002 e 2016. Primary outcome was de fi ned as in-hospital mortality. Secondary outcomes included 1-year mortality, valvular surgical intervention, heart failure, stroke and systemic embolization. Results : In total, 196 patients with de fi nite or possible IE were included in the study. The incidence of IE was 2.26 per 100,000 person-years and had remained stable. Health care-associated IE (HCAIE) accounted for 32% of cases, with an increasing trend. Staphylococcus aureus was the most frequently isolated organism in the overall study population (37.8%) and among intravenous drug users (85.2%). In-hospital mortality remained high (29.1%) and was independently associated with higher Charlson Comorbidity Index (OR 1.24, p ¼ 0.001), heart failure (OR 5.65, p < 0.001) and the presence of large vegetation ≥ 1 cm (OR 4.67, p < 0.001). IE due to Streptococcus viridans was associated with a better outcome (OR 0.40, p ¼ 0.048). Discussion : This study showed that the incidence of IE remained stable during 2002 e 2016. There was an increasing proportion of HCAIE and S. aureus has become the most common causative organism. IE was associated with high mortality and morbidity. Independent predictors for in-hospital mortality were patient ' s medical comorbidity, large vegetation size and heart failure, while infection by viridans group streptococci was associated with reduced risk.","PeriodicalId":53534,"journal":{"name":"Journal of the Hong Kong College of Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"A Retrospective Study on the Predictors of Outcome in Patients with Infective Endocarditis\",\"authors\":\"Y. Yiu\",\"doi\":\"10.55503/2790-6744.1070\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background : Infective endocarditis (IE) is associated with signi fi cant mortality and morbidity. This study aims to up-date the epidemiology of IE and to identify predictors of adverse outcome in the Chinese population in Hong Kong. Methods : This was a single-centre retrospective study of patients diagnosed with IE in Princess Margaret Hospital in Hong Kong during 2002 e 2016. Primary outcome was de fi ned as in-hospital mortality. Secondary outcomes included 1-year mortality, valvular surgical intervention, heart failure, stroke and systemic embolization. Results : In total, 196 patients with de fi nite or possible IE were included in the study. The incidence of IE was 2.26 per 100,000 person-years and had remained stable. Health care-associated IE (HCAIE) accounted for 32% of cases, with an increasing trend. Staphylococcus aureus was the most frequently isolated organism in the overall study population (37.8%) and among intravenous drug users (85.2%). In-hospital mortality remained high (29.1%) and was independently associated with higher Charlson Comorbidity Index (OR 1.24, p ¼ 0.001), heart failure (OR 5.65, p < 0.001) and the presence of large vegetation ≥ 1 cm (OR 4.67, p < 0.001). IE due to Streptococcus viridans was associated with a better outcome (OR 0.40, p ¼ 0.048). Discussion : This study showed that the incidence of IE remained stable during 2002 e 2016. There was an increasing proportion of HCAIE and S. aureus has become the most common causative organism. IE was associated with high mortality and morbidity. Independent predictors for in-hospital mortality were patient ' s medical comorbidity, large vegetation size and heart failure, while infection by viridans group streptococci was associated with reduced risk.\",\"PeriodicalId\":53534,\"journal\":{\"name\":\"Journal of the Hong Kong College of Cardiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-03-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Hong Kong College of Cardiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.55503/2790-6744.1070\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Hong Kong College of Cardiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55503/2790-6744.1070","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
A Retrospective Study on the Predictors of Outcome in Patients with Infective Endocarditis
Background : Infective endocarditis (IE) is associated with signi fi cant mortality and morbidity. This study aims to up-date the epidemiology of IE and to identify predictors of adverse outcome in the Chinese population in Hong Kong. Methods : This was a single-centre retrospective study of patients diagnosed with IE in Princess Margaret Hospital in Hong Kong during 2002 e 2016. Primary outcome was de fi ned as in-hospital mortality. Secondary outcomes included 1-year mortality, valvular surgical intervention, heart failure, stroke and systemic embolization. Results : In total, 196 patients with de fi nite or possible IE were included in the study. The incidence of IE was 2.26 per 100,000 person-years and had remained stable. Health care-associated IE (HCAIE) accounted for 32% of cases, with an increasing trend. Staphylococcus aureus was the most frequently isolated organism in the overall study population (37.8%) and among intravenous drug users (85.2%). In-hospital mortality remained high (29.1%) and was independently associated with higher Charlson Comorbidity Index (OR 1.24, p ¼ 0.001), heart failure (OR 5.65, p < 0.001) and the presence of large vegetation ≥ 1 cm (OR 4.67, p < 0.001). IE due to Streptococcus viridans was associated with a better outcome (OR 0.40, p ¼ 0.048). Discussion : This study showed that the incidence of IE remained stable during 2002 e 2016. There was an increasing proportion of HCAIE and S. aureus has become the most common causative organism. IE was associated with high mortality and morbidity. Independent predictors for in-hospital mortality were patient ' s medical comorbidity, large vegetation size and heart failure, while infection by viridans group streptococci was associated with reduced risk.
期刊介绍:
The Journal of the Hong Kong College of Cardiology publishes peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, review articles and experimental investigations. As official journal of the Hong Kong College of Cardiology, the journal publishes abstracts of reports to be presented at the Scientific Sessions of the College as well as reports of the College-sponsored conferences.