通过光血栓形成模拟短暂性脑缺血发作

IF 4.9 Q1 BIOPHYSICS
Biophysical reviews Pub Date : 2023-09-04 eCollection Date: 2023-10-01 DOI:10.1007/s12551-023-01121-1
Y N Kalyuzhnaya, A M Khaitin, S V Demyanenko
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引用次数: 0

摘要

短暂性脑缺血发作(tia)的健康意义在很大程度上被低估了。通常,tia并没有被给予显著的重视,而且是徒劳的,因为tia是严重心血管疾病甚至死亡的预测因子。正因为如此,也因为诊断疾病的困难,tia和相关的微梗死很少被研究。脑卒中和TIA的光血栓模型允许再现小脑血管,甚至单个脑血管的闭塞。当给予光敏剂浓度、强度和照射时间时,有可能实现明确的小血管的闭塞,具有高重复性,并且在现代血流评估方法的帮助下,有可能实现血流的自发恢复而不导致血管破裂。在这篇综述中,我们讨论了微梗死的特征和用于模拟TIA和微梗死的当代实验方法,重点是利用脑血管光血栓形成原理的模型。我们回顾了小脑血管血流体内检测的现代技术,以及微梗死的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Modeling transient ischemic attack via photothrombosis.

The health significance of transient ischemic attacks (TIAs) is largely underestimated. Often, TIAs are not given significant importance, and in vain, because TIAs are a predictor of the development of serious cardiovascular diseases and even death. Because of this, and because of the difficulty in diagnosing the disease, TIAs and related microinfarcts are poorly investigated. Photothrombotic models of stroke and TIA allow reproducing the occlusion of small brain vessels, even single ones. When dosing the concentration of photosensitizer, intensity and irradiation time, it is possible to achieve occlusion of well-defined small vessels with high reproducibility, and with the help of modern methods of blood flow assessment it is possible to achieve spontaneous restoration of blood flow without vessel rupture. In this review, we discuss the features of microinfarcts and the contemporary experimental approaches used to model TIA and microinfarcts, with an emphasis on models using the principle of photothrombosis of brain vessels. We review modern techniques for in vivo detection of blood flow in small brain vessels, as well as biomarkers of microinfarcts.

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来源期刊
Biophysical reviews
Biophysical reviews Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
8.90
自引率
0.00%
发文量
93
期刊介绍: Biophysical Reviews aims to publish critical and timely reviews from key figures in the field of biophysics. The bulk of the reviews that are currently published are from invited authors, but the journal is also open for non-solicited reviews. Interested authors are encouraged to discuss the possibility of contributing a review with the Editor-in-Chief prior to submission. Through publishing reviews on biophysics, the editors of the journal hope to illustrate the great power and potential of physical techniques in the biological sciences, they aim to stimulate the discussion and promote further research and would like to educate and enthuse basic researcher scientists and students of biophysics. Biophysical Reviews covers the entire field of biophysics, generally defined as the science of describing and defining biological phenomenon using the concepts and the techniques of physics. This includes but is not limited by such areas as: - Bioinformatics - Biophysical methods and instrumentation - Medical biophysics - Biosystems - Cell biophysics and organization - Macromolecules: dynamics, structures and interactions - Single molecule biophysics - Membrane biophysics, channels and transportation
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