43-O-(β- d -葡萄糖苷)-雷帕霉素是枯草芽孢杆菌CGMCC7764的微生物转化产物

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biocatalysis and Biotransformation Pub Date : 2022-08-25 DOI:10.1080/10242422.2022.2108707

Xiaoming Chen, Guohua Yang, Xiaqin Chen, Dong-Wei Jin, Hui Yu, Yuan-rong Cheng, Jie Huang

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引用次数: 0

摘要

雷帕霉素是一种大环内酯类抗生素，具有抗真菌、免疫抑制、抗肿瘤和延长寿命等活性。为了增加其结构多样性，对雷帕霉素进行了微生物转化。枯草芽孢杆菌CGMCC7764在雷帕霉素的微生物转化培养基中显示了3种以上的转化化合物。通过核磁共振和质谱分析，确定主要化合物为43-O-（β-D-葡萄糖苷）-雷帕霉素。这种化合物对肿瘤生长有抑制作用，其活性与雷帕霉素相似。

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43-O-(β-D-glucoside)-rapamycin, a microbial conversion product by Bacillus subtilis CGMCC7764

Abstract Rapamycin is a macrolide antibiotic with antifungal, immunosuppressive, antitumor, and lifespan-extension activities etc. In order to increase its structural diversity, microbial transformation of rapamycin was conducted. More than 3 converted compounds were shown in the microbial conversion culture of rapamycin by Bacillus subtilis CGMCC7764. By extensive NMR and MS spectroscopic analyses, the major compound was identified as 43-O-(β-D-glucoside)-rapamycin. This compound has an inhibitory effect on tumour growth, and its activity is similar to rapamycin.

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来源期刊

Biocatalysis and Biotransformation 生物-生化与分子生物学

CiteScore

4.40

自引率

5.60%

发文量

审稿时长

3 months

期刊介绍： Biocatalysis and Biotransformation publishes high quality research on the application of biological catalysts for the synthesis, interconversion or degradation of chemical species. Papers are published in the areas of: Mechanistic principles Kinetics and thermodynamics of biocatalytic processes Chemical or genetic modification of biocatalysts Developments in biocatalyst''s immobilization Activity and stability of biocatalysts in non-aqueous and multi-phasic environments, including the design of large scale biocatalytic processes Biomimetic systems Environmental applications of biocatalysis Metabolic engineering Types of articles published are; full-length original research articles, reviews, short communications on the application of biotransformations, and preliminary reports of novel catalytic activities.