{"title":"肾移植术后甲型疱疹病毒感染的处理(7例)","authors":"Hirofumi Uehara, Hajime Hirano, Tomohisa Matsunaga, Koichiro Minami, Kazumasa Komura, Naokazu Ibuki, Teruo Inamoto, Hayahito Nomi, Haruhito Azuma","doi":"10.1016/j.tpr.2020.100051","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Kidney transplantation is the definitive treatment for patients with end-stage kidney diseases. Quality of life and longevity following transplantation are nearly equal to those of healthy individuals. Immunosuppression has improved graft survival but leaves the patient susceptible to viral infections. Alpha-herpesviruses belong to a subfamily of herpesviruses and are widely distributed in nature. The human alpha-herpesviruses include herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella zoster virus (VZV). HSV-1, HSV-2 and VZV often reactivate in the setting of immune suppression after kidney transplantation. The management of infectious disease in transplantation are major contributors to improved outcomes in organ transplantation.</p></div><div><h3>Objectives</h3><p>The aim of this study was to report cases of alpha-herpesvirus infection following kidney transplantation.</p></div><div><h3>Methods</h3><p>From July 2014 to December 2018, we performed 55 kidney transplantations at Osaka Medical College Hospital. All alpha-herpesvirus infection cases following kidney transplantation were retrospectively evaluated.</p></div><div><h3>Results</h3><p>We treated 7 patients with alpha-herpesvirus infection. Median age was 60; 2 patients were female. All patients were able to be treated with acyclovir and valacyclovir. A patient was complicated by postherpetic neuraglia (chronic pain). A patient was complicated by secondary bacterial infection and treated with antibiotic.</p></div><div><h3>Conclusion</h3><p>The human alpha-herpesviruses include HSV-1, HSV-2 and VZV often reactivate after kidney transplantation. This case report demonstrates the successful medical treatment of alpha-herpesvirus infection cases following kidney transplantation.</p></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tpr.2020.100051","citationCount":"0","resultStr":"{\"title\":\"Management of alpha-herpesvirus infection following kidney transplantation: Our experience (7 cases)\",\"authors\":\"Hirofumi Uehara, Hajime Hirano, Tomohisa Matsunaga, Koichiro Minami, Kazumasa Komura, Naokazu Ibuki, Teruo Inamoto, Hayahito Nomi, Haruhito Azuma\",\"doi\":\"10.1016/j.tpr.2020.100051\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Kidney transplantation is the definitive treatment for patients with end-stage kidney diseases. Quality of life and longevity following transplantation are nearly equal to those of healthy individuals. Immunosuppression has improved graft survival but leaves the patient susceptible to viral infections. Alpha-herpesviruses belong to a subfamily of herpesviruses and are widely distributed in nature. The human alpha-herpesviruses include herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella zoster virus (VZV). HSV-1, HSV-2 and VZV often reactivate in the setting of immune suppression after kidney transplantation. The management of infectious disease in transplantation are major contributors to improved outcomes in organ transplantation.</p></div><div><h3>Objectives</h3><p>The aim of this study was to report cases of alpha-herpesvirus infection following kidney transplantation.</p></div><div><h3>Methods</h3><p>From July 2014 to December 2018, we performed 55 kidney transplantations at Osaka Medical College Hospital. All alpha-herpesvirus infection cases following kidney transplantation were retrospectively evaluated.</p></div><div><h3>Results</h3><p>We treated 7 patients with alpha-herpesvirus infection. Median age was 60; 2 patients were female. All patients were able to be treated with acyclovir and valacyclovir. A patient was complicated by postherpetic neuraglia (chronic pain). A patient was complicated by secondary bacterial infection and treated with antibiotic.</p></div><div><h3>Conclusion</h3><p>The human alpha-herpesviruses include HSV-1, HSV-2 and VZV often reactivate after kidney transplantation. This case report demonstrates the successful medical treatment of alpha-herpesvirus infection cases following kidney transplantation.</p></div>\",\"PeriodicalId\":37786,\"journal\":{\"name\":\"Transplantation Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.tpr.2020.100051\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transplantation Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2451959620300135\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transplantation Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451959620300135","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Management of alpha-herpesvirus infection following kidney transplantation: Our experience (7 cases)
Background
Kidney transplantation is the definitive treatment for patients with end-stage kidney diseases. Quality of life and longevity following transplantation are nearly equal to those of healthy individuals. Immunosuppression has improved graft survival but leaves the patient susceptible to viral infections. Alpha-herpesviruses belong to a subfamily of herpesviruses and are widely distributed in nature. The human alpha-herpesviruses include herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella zoster virus (VZV). HSV-1, HSV-2 and VZV often reactivate in the setting of immune suppression after kidney transplantation. The management of infectious disease in transplantation are major contributors to improved outcomes in organ transplantation.
Objectives
The aim of this study was to report cases of alpha-herpesvirus infection following kidney transplantation.
Methods
From July 2014 to December 2018, we performed 55 kidney transplantations at Osaka Medical College Hospital. All alpha-herpesvirus infection cases following kidney transplantation were retrospectively evaluated.
Results
We treated 7 patients with alpha-herpesvirus infection. Median age was 60; 2 patients were female. All patients were able to be treated with acyclovir and valacyclovir. A patient was complicated by postherpetic neuraglia (chronic pain). A patient was complicated by secondary bacterial infection and treated with antibiotic.
Conclusion
The human alpha-herpesviruses include HSV-1, HSV-2 and VZV often reactivate after kidney transplantation. This case report demonstrates the successful medical treatment of alpha-herpesvirus infection cases following kidney transplantation.
期刊介绍：
To provide to national and regional audiences experiences unique to them or confirming of broader concepts originating in large controlled trials. All aspects of organ, tissue and cell transplantation clinically and experimentally. Transplantation Reports will provide in-depth representation of emerging preclinical, impactful and clinical experiences. -Original basic or clinical science articles that represent initial limited experiences as preliminary reports. -Clinical trials of therapies previously well documented in large trials but now tested in limited, special, ethnic or clinically unique patient populations. -Case studies that confirm prior reports but have occurred in patients displaying unique clinical characteristics such as ethnicities or rarely associated co-morbidities. Transplantation Reports offers these benefits: -Fast and fair peer review -Rapid, article-based publication -Unrivalled visibility and exposure for your research -Immediate, free and permanent access to your paper on Science Direct -Immediately citable using the article DOI
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