应用毒理学研究

Q2 Agricultural and Biological Sciences
J. Gu
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引用次数: 3

摘要

分析化学可以准确量化生态系统和受污染地点不同介质中一系列化学品的总浓度,但数值与它们的毒性没有直接相关性,因为测量的浓度并不代表对生物体产生毒性影响的活性部分。显然,生态系统中污染物浓度的评估应采用新的创新方法,以获得生物体暴露浓度,从而基于这些数据的后续毒理学影响能够为相应的管理决策提供可靠的毒性估计。因此,应用毒理学,如生态毒理学和环境毒理学,应具有不同的科学框架,采用新的污染物浓度术语,在生态系统中的有效浓度和对生物体的毒性之间建立密切关系,以对生态毒理学和环境毒性有意义的理解。此外,选择生物体作为化学毒性测定的指标是另一个关键问题,应在国际共识的基础上选择生物体,为世界各地不同实验室的可比结果建立坚实的基线。通过这种方式,应用毒理学可以在与当今物理科学类似的精确科学的基础上,在更具竞争力的水平上取得巨大进步,并为社会做出更好的贡献。一个更大的机会就在前方,需要立即集体采取有效行动来推进这一研究主题的新知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
On Applied Toxicology
Analytical chemistry allows an accurate quantification of the total concentrations of a range of chemicals in different media of the ecosystems and contaminated sites, but the numerical values do not have direct relevance to the toxicity of them because the measured concentrations do not represent the active fraction that imposes toxic effects on organisms. It is apparent that an assessment of pollutant concentrations in ecosystems shall be made with new innovation to obtain the organism exposed concentrations so that the subsequent toxicological effects based on these data can provide reliable estimate on toxicity for management decision accordingly. Applied Toxicology, e.g., Ecotoxicology, and Environmental Toxicology, therefore shall have a different scientific framework to adopt the use of a new concentration term for pollutants to establish a close relationship between the effective concentration in the ecosystem and the toxicity to the organisms to make a meaningful understanding of the ecotoxicology and environmental toxicity. In addition, the choice of the organisms as indicators for chemical toxicity assays is another critical issue and the organism shall be selected with an international consensus to establish a solid baseline for comparable results from different laboratories around the world. Doing this way, the Applied Toxicology can make great advancement and contributes to the society better on a more competitive level based on exact science similar to physical sciences today. A greater opportunity is ahead and effective action needs to be taken collectively and immediately to advance the new knowledge of this research subject.
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来源期刊
Applied Environmental Biotechnology
Applied Environmental Biotechnology Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)
CiteScore
3.70
自引率
0.00%
发文量
2
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