Vahid Iranpur Mobarakeh, M. Modarressi, P. Rahimi, A. Bolhassani, E. Arefian
{"title":"用于siRNA递送的SPION纳米载体的修饰：一种对抗HIV感染的治疗策略","authors":"Vahid Iranpur Mobarakeh, M. Modarressi, P. Rahimi, A. Bolhassani, E. Arefian","doi":"10.29252/vacres.6.1.43","DOIUrl":null,"url":null,"abstract":"and the effectiveness of the modified SPION in siRNA delivery to HEK293 cells was evaluated. Results: The optimal concentration (50 µg/mL) of the modified SPION-containing anti-tat siRNA (with a range size of 50-70 nm and average zeta potential of +25 mV) was significantly internalized into the cells and decreased the expression of HIV-1 tat, more than 80%. Moreover, the nanoparticles showed no considerable toxicity on the cells. Conclusion: SPION could be optimized as a probable RNA/vaccine delivery system into target cells. Therefore, this study offers a therapeutic strategy against HIV or other infectious diseases.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Modification of SPION nanocarriers for siRNA delivery: A therapeutic strategy against HIV infection\",\"authors\":\"Vahid Iranpur Mobarakeh, M. Modarressi, P. Rahimi, A. Bolhassani, E. Arefian\",\"doi\":\"10.29252/vacres.6.1.43\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"and the effectiveness of the modified SPION in siRNA delivery to HEK293 cells was evaluated. Results: The optimal concentration (50 µg/mL) of the modified SPION-containing anti-tat siRNA (with a range size of 50-70 nm and average zeta potential of +25 mV) was significantly internalized into the cells and decreased the expression of HIV-1 tat, more than 80%. Moreover, the nanoparticles showed no considerable toxicity on the cells. Conclusion: SPION could be optimized as a probable RNA/vaccine delivery system into target cells. Therefore, this study offers a therapeutic strategy against HIV or other infectious diseases.\",\"PeriodicalId\":52727,\"journal\":{\"name\":\"Vaccine Research\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vaccine Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29252/vacres.6.1.43\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vaccine Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29252/vacres.6.1.43","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Modification of SPION nanocarriers for siRNA delivery: A therapeutic strategy against HIV infection
and the effectiveness of the modified SPION in siRNA delivery to HEK293 cells was evaluated. Results: The optimal concentration (50 µg/mL) of the modified SPION-containing anti-tat siRNA (with a range size of 50-70 nm and average zeta potential of +25 mV) was significantly internalized into the cells and decreased the expression of HIV-1 tat, more than 80%. Moreover, the nanoparticles showed no considerable toxicity on the cells. Conclusion: SPION could be optimized as a probable RNA/vaccine delivery system into target cells. Therefore, this study offers a therapeutic strategy against HIV or other infectious diseases.
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