甘菊在亚砷酸钠诱导的组织损伤中的作用

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2022-09-06 DOI:10.3329/bjp.v17i3.59819

Hashim Achummantakath, Krishnan Subhadra Prasanna, A. S. Nizamudeen

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引用次数: 0

摘要

本研究旨在评价苦叶醇提物对砷诱导的Wistar大鼠组织学变化的影响。将大鼠分为4组：第一组：正常对照组；第二组：大鼠接受亚砷酸钠（40mg/kg）；第三组：大鼠接受亚砷酸钠（40mg/kg）+苦杏仁提取物（100mg/kg）；第IV组：大鼠接受亚砷酸钠（40mg/kg）+提取物（200mg/kg）。所有组均用亚砷酸钠经口灌胃治疗28天，随后用100和200mg/kg提取物（口服）给药，每天一次，持续两周。最后一次治疗后24小时处死动物，收集不同的器官进行组织病理学分析。结果显示，砷喂养的动物大脑、肾脏和肝脏出现轻度至重度坏死和退行性变化。在给予提取物的大鼠中显示出显著的改善，并且在大鼠中细胞的正常组织学特征几乎恢复。这些结果表明，苦杏仁可用于治疗砷引起的多器官损伤。

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Effect of Phyllanthus amarus in sodium arsenite-induced tissue damage

This study aims to evaluate the effect of alcoholic extract of Phyllanthus amarus leaves on arsenic-induced histological changes in Wistar rats. Rats were divided into 4 groups: Group I: normal control; Group II: rats received sodium arsenite (40 mg/kg); Group III: rats received sodium arsenite (40 mg/kg) + P. amarus extract (100 mg/kg); Group IV: rats received sodium arsenite (40 mg/kg) + extract (200 mg/kg). All groups were treated by oral gavage with sodium arsenite for 28 days and the animals were subsequently administered (oral) with 100 and 200 mg/kg extract, once daily for two weeks. Animals were sacrificed 24 hours after the last treatment and different organs were collected for histopathological analysis. Results revealed mild to severe type of necrosis and degenerative changes in brain, kidney, and liver of arsenic fed animals. In rats administered with extract showed significant improvements, and the normal histological feature of the cells was almost restored in rats. These suggest that P. amarus can be used to treat arsenic-induced multi-organ damages.

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.