狮子鱼(Pterois)和石鱼(Synanceja)毒液药理特性的评价

Q4 Pharmacology, Toxicology and Pharmaceutics
K. Ramalingam
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引用次数: 0

摘要

在过去的70年里,研究的重点是寻找在有毒和有毒生物中发现的毒素和毒素,纯粹是针对毒素的药理学性质。在药物研究中寻找新化合物的研究中,鉴定的来源是鱼毒液。Scorpaenidae家族被认为是所有家族中最毒的。从石鱼和狮子鱼中分离出来的毒素会对心血管和神经肌肉系统造成影响,也会导致细胞溶解活动。本文的主要目的是研究石鱼毒液的作用机制,并描述其在药物开发领域的益处。研究了石鱼毒液诱导心血管内皮的作用机制。在兔、猪动脉、小鼠和大鼠的神经肌肉系统中,神经递质信号的释放通过在细胞膜上形成孔隙导致细胞膜去极化。狮子鱼的毒液在与石鱼的毒液发生交叉反应的结果中进化出了一种活性。在狮子鱼的初级结构中存在的酶透明质酸酶是从石鱼进化而来的,由于它们具有生物和化学活性,它们的抗癌潜力也被证明对药物发现有好处。本文综述了狮子鱼毒液与石鱼毒液的药理作用及其在药物开发中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of the Pharmacological Properties of Piscine Venoms from both Lionfish (Pterois) and Stonefish (Synanceja)
For the past 70 years, the focus of research is on the search for poisons and toxins found in venomous and poisonous organisms, purely directed towards the pharmacological properties of the toxins. In the research of finding novel compounds in pharmaceutical research, the identified source was the piscine venom. The Scorpaenidae family was considered the most venomous of all. The toxins isolated from stonefish and lionfish are responsible for the effects caused in cardiovascular and neuromuscular systems and also for causing cytolytic activities. The main objective of the review is to study the mechanism of the stonefish venom and portray its benefits in the field of drug discovery. A study on the mechanism of stonefish venom was carried out by inducing cardiovascular endothelium. The release of neurotransmitter signals thus leads to the depolarisation of cell membrane by the formation of pores in the cell membrane in the neuromuscular system of rabbits, porcine artery, mice and rats. Lionfish venom in cross-reactivity with the results evolved from a stonefish venom activity. The presence of enzymatic hyaluronidases in the primary structures of lionfish has evolved from stonefish and their anticancer potential has also been demonstrated for the benefits of drug discovery as they possess biological and chemical activity. This review depicts an overview of the pharmacological activities of lionfish venom in comparison with the stonefish venom and their purpose of applications for future research in drug discovery.
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来源期刊
Current Enzyme Inhibition
Current Enzyme Inhibition Pharmacology, Toxicology and Pharmaceutics-Drug Discovery
CiteScore
1.30
自引率
0.00%
发文量
30
期刊介绍: Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.
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