生物安全和心理健康:病毒引起的认知能力下降

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Biosafety and Health Pub Date : 2023-06-01 DOI:10.1016/j.bsheal.2023.04.002

Chunxiao Du, Ge Li, Gencheng Han

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引用次数: 0

摘要

生物制剂通过不同的方式威胁着人们的生命，其中之一就是认知障碍。人们认为认知能力下降可能是由生物制剂介导的神经元损伤直接引起的，或者是由激活宿主免疫反应来根除病原体引起的。然而，感染和认知能力下降之间的直接联系非常有限。在这里，我们关注不同的生物病毒或它们诱导的全身和局部炎症如何与认知障碍联系的机制，重点关注激活的小胶质细胞和几种分子途径介导的神经毒性的作用。

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Biosafety and mental health: Virus induced cognitive decline

Biological agents threats people's life through different ways, one of which lies in the impairment of cognition. It is believed cognitive decline may result from biological agents mediated neuron damage directly, or from the activation of the host immune response to eradicate the pathogen. However, direct linkage between infections and cognitive decline is very limited. Here we focus on the mechanisms of how different biological virus or they induced systemic and local inflammation link to the cognitive impairment, focusing on the roles of activated microglia and several molecular pathways mediated neurotoxicity.

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