动态组合化学中的肽和拟肽组装体

IF 3.1 Q2 CHEMISTRY, MULTIDISCIPLINARY
Ashmi Rodrigues, Dr. Lou Rocard, Dr. Roba Moumné
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引用次数: 0

摘要

在过去的几年里,人们对多肽的兴趣在不同的领域得到了强烈的复兴,包括药物发现、生物传感和材料科学。动态共价化学的使用已经允许开发自适应肽或肽拟物,对其环境作出反应。建立、筛选或反卷积肽库的方法的发展是一个高度活跃的研究领域,动态组合化学代表了该领域的一种创新和未开发的方法。本文综述了动态共价化学在合成多肽或拟肽物方面的应用,重点介绍了动态组合化学的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Peptide and Peptidomimetic Assemblies in Dynamic Combinatorial Chemistry

Peptide and Peptidomimetic Assemblies in Dynamic Combinatorial Chemistry

A strong revival of interest has been dedicated to peptides over the last few years, in different fields including drug discovery, biosensing and material sciences. The use of dynamic covalent chemistry has allowed the development of self-adaptative peptides or peptidomimetics, responsive to their environment. The development of methods allowing the building, screening or deconvolution of libraries of peptides is a highly active research area and dynamic combinatorial chemistry represents an innovative and underexploited method in this field. This Review gives an overview of the use of dynamic covalent chemistry as a tool to produce peptides or peptidomimetics, with particular attention to applications in dynamic combinatorial chemistry.

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