1-苯基-3-甲基-4-正氟苯甲酰-5-吡唑啉酮修饰的多壁碳纳米管电极传感多巴胺的电化学传感器

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-05-12 DOI:10.4314/bcse.v37i4.4

Emi Norzehan Mohamad Mahbob, Mohamad Syahrizal Ahmad, Illyas Md Isa, N. Hashim, A. ul-Hamid, Mohamad Idris Saidin, Suyanta M. Si

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引用次数: 1

摘要

摘要。本文阐述了一种利用1-苯基-3-甲基-4-邻氟苯甲酰基-5-吡唑啉酮（HPMoFBP）/多壁碳纳米管（MWCNT）碳糊电极（CPE）电化学检测多巴胺（DOP）的简单、快速、灵敏的方法。通过循环伏安法和方波伏安法研究了DOP的电化学行为。与裸MWCNT相比，HPMoFBP/MWCNT在DOP氧化的较低电势下显示出较高的电流。在pH 8.0的1.0 x 10-1M磷酸盐缓冲盐水（PBS）溶液中检测到传感器改进的电催化活性。在1至1000µM范围内的电响应和DOP浓度之间观察到良好的线性回归分析。在优化的实验条件下，确定1.0×10-7M为检测限（LOD）。该传感器在没有干扰的情况下对DOP检测表现出相当高的灵敏度，并成功用于测定盐酸多巴胺注射液中的DOP。关键词：电化学传感器，多巴胺，吡唑酮，MWCNT，伏安法。化学。Soc.Ethiop。2023,37（4），845-857.DOI:https://dx.doi.org/10.4314/bcse.v37i4.4

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Electrochemical sensor of multiwalled carbon nanotube electrode modified by 1-phenyl-3-methyl-4-orthofluoro benzoyl-5-pyrazolone for sensing dopamine

ABSTRACT. This work explicates a simple, rapid, and sensitive method for the electrochemical detection of dopamine (DOP) utilising 1-phenyl-3-methyl-4-orthofluorobenzoyl-5-pyrazolone (HPMoFBP)/multiwalled carbon nanotube (MWCNT) carbon paste electrode (CPE). The electrochemical behaviour of DOP was performed through cyclic voltammetry and square wave voltammetry. HPMoFBP/MWCNT showed a higher current at the lower potential for the oxidation of DOP compared to bare MWCNT. The sensor's improved electrocatalytic activity was observed to detect in a 1.0 x 10-1 M phosphate buffer saline (PBS) solution at pH 8.0. A good linear regression analysis was observed between electrical response and the concentration of DOP in the range of 1 to 1000 µM. Under optimized experimental conditions, 1.0 x 10-7 M has been determined as the limit of detection (LOD). The sensor has expressed considerable sensitivity towards DOP detection without interference and is successfully used to determine DOP in dopamine hydrochloride injection. KEY WORDS: Electrochemical sensor, Dopamine, Pyrazolone, MWCNT, Voltammetry Bull. Chem. Soc. Ethiop. 2023, 37(4), 845-857. DOI: https://dx.doi.org/10.4314/bcse.v37i4.4

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来源期刊

Bulletin of the Chemical Society of Ethiopia 化学-化学综合

CiteScore

2.20

自引率

8.30%

发文量

113

审稿时长

6-12 weeks

期刊介绍： The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.