用于疾病诊断和药物递送应用的病毒样颗粒

IF 1.4 4区材料科学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Current Nanoscience Pub Date : 2023-07-17 DOI:10.2174/1573413719666230717123734

R. Malviya, Rishav Sharma

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引用次数: 0

摘要

病毒样颗粒（VLP）是由蛋白质制成的纳米级自组装笼状结构，在生物医学中具有实际用途。它们可能被用于制造更好的疫苗接种、成像设备、基因和药物治疗递送系统以及体外诊断设备。VLP是一种纳米结构，可用于医学、免疫和诊断等领域。许多基于VLP的疫苗目前正在用于治疗传染病，由于生物医学工程的最新进展，更多的疫苗正在进行临床测试。尽管VLP在疗效、安全性和多样性方面表现出有希望的品质，但它们在未来可能会得到更广泛的应用。基于病毒样颗粒（VLP）的疫苗可能是目前预防和治疗新发传染病的免疫策略的有效补充。日益增长的医疗保健预防领域对VLP越来越感兴趣，从而发现了各种基于VLP的候选疫苗，用于针对各种传染性病原体进行疫苗接种，最近开发的疫苗之一是针对严重急性呼吸系统综合征冠状病毒2型的疫苗，其有效性目前正在测试中。与标准灭活病毒疫苗不同，VLP可以引发抗体和细胞介导的免疫反应。然而，这种表面显示方法仍然存在一些问题，并且在未来需要解决。基于VLP的药物递送、用于治疗的纳米反应器和成像系统正在开发中，并取得了有希望的结果。VLP的产生和制造的最新进展涉及对其产生的几种表达系统的探索，以及其作为避免传染病和恶性肿瘤的疫苗的应用。本文提供了基于VLP的生物医学应用的最先进视角，并详细介绍了VLP的制造、功能化和递送的创新方法。

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Virus-like Particles for Disease Diagnosis and Drug Delivery Applications

Virus-like particles (VLPs) are nanoscale, self-assembling cage structures made out of proteins with practical uses in biomedicine. They might be used to create better vaccinations, imaging equipment, gene and drug therapy delivery systems, and in vitro diagnostic equipment. VLPs are nanostructures that might be used in medicine, immunization, and diagnostics, among other areas. Many VLPs-based vaccines are now in use for the treatment of infectious diseases, and many more are on their way to clinical testing thanks to recent advancements in biomedical engineering. Although VLPs exhibit promising qualities in terms of efficacy, safety, and diversity, they may become more widely used in the future. Vaccines based on virus-like particles (VLPs) might serve as an effective addition to current immunization strategies for the prevention and treatment of emerging infectious diseases. The growing field of healthcare prevention has become increasingly interested in VLPs, leading to the discovery of various VLP-based candidate vaccines for vaccination towards a wide range of infectious pathogens, one of the most recent that has been developed is the vaccine against SARS-CoV-2, the effectiveness of that is now being tested. VLPs can elicit both antibody and cell-mediated immune responses, unlike standard inactivated viral vaccines. However, several problems persist with this surface display method and will need fixing in the future. VLPs-based medicinal delivery, nanoreactors for treatment, and imaging systems are being developed with promising results. The latest developments in the generation and fabrication of VLPs involve explorations of several expression systems for their creation and their application as vaccines for the avoidance of infectious diseases and malignancies. This manuscript offers the most advanced perspective on biomedical applications based on VLPs, as well as details innovative methods for manufacturing, functionalization, and delivery of VLPs.

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来源期刊

Current Nanoscience 工程技术-材料科学：综合

CiteScore

3.50

自引率

6.70%

发文量

审稿时长

4.4 months

期刊介绍： Current Nanoscience publishes (a) Authoritative/Mini Reviews, and (b) Original Research and Highlights written by experts covering the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano-structures, nano-bubbles, nano-droplets and nanofluids. Applications of nanoscience in physics, material science, chemistry, synthesis, environmental science, electronics, biomedical nanotechnology, biomedical engineering, biotechnology, medicine and pharmaceuticals are also covered. The journal is essential to all researches involved in nanoscience and its applied and fundamental areas of science, chemistry, physics, material science, engineering and medicine. Current Nanoscience also welcomes submissions on the following topics of Nanoscience and Nanotechnology: Nanoelectronics and photonics Advanced Nanomaterials Nanofabrication and measurement Nanobiotechnology and nanomedicine Nanotechnology for energy Sensors and actuator Computational nanoscience and technology.