新冠肺炎疫苗接种相关疼痛与皮肤活检异常无关

IF 3.4 Q2 NEUROSCIENCES
Pain Reports Pub Date : 2023-08-10 eCollection Date: 2023-09-01 DOI:10.1097/PR9.0000000000001089
Giulia Di Stefano, Pietro Falco, Eleonora Galosi, Gianfranco De Stefano, Giuseppe Di Pietro, Caterina Leone, Daniel Litewczuk, Lorenzo Tramontana, Stefano Strano, Andrea Truini
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引用次数: 0

摘要

补充数字内容可在文本中获得。与COVID-19疫苗接种相关的全身感觉症状和疼痛与皮肤活检异常无关,可能与纤维肌痛综合征有关。先前的临床观察提出了COVID-19疫苗接种可能引发小纤维神经病变的可能性。目的:在这项无对照观察性研究中,我们旨在确定在COVID-19疫苗接种后抱怨全身感觉症状和疼痛的患者的小纤维损伤。方法:我们收集临床资料,包括评估自主神经症状的问卷(复合自主神经症状评分-31),并对15例前瞻性纳入的COVID-19疫苗接种后出现全身感觉症状和疼痛的患者进行定量感觉测试(QST)和皮肤活检。9例主诉直立不耐受的患者也进行了心血管自主神经测试。结果:我们发现所有患者都经历了广泛的疼痛,其中大多数(15例中的11例)患有纤维肌痛综合征。所有患者的皮肤活检结果均正常,在9例站立性不耐受患者中,心血管自主神经试验显示正常。然而,在QST调查中,有5例患者出现冷热检测异常。结论:在我们的研究中,大多数在COVID-19疫苗接种后抱怨全身感觉症状和疼痛的患者的临床和诊断检查结果与纤维肌痛综合征相符。虽然我们在5例患者中发现的异常QST结果可能与小纤维神经病变相符,但考虑到该诊断测试的心理物理特征,应谨慎解释。需要进一步进行更大规模的对照研究,以准确定义小纤维损伤与COVID-19疫苗接种之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pain associated with COVID-19 vaccination is unrelated to skin biopsy abnormalities.

Introduction: Previous clinical observations raised the possibility that COVID-19 vaccination might trigger a small-fibre neuropathy.

Objectives: In this uncontrolled observational study, we aimed to identify small fibre damage in patients complaining of generalized sensory symptoms and pain after COVID-19 vaccination.

Methods: We collected clinical data, including a questionnaire for assessing autonomic symptoms (Composite Autonomic Symptom Score-31), and investigated quantitative sensory testing (QST) and skin biopsy in 15 prospectively enrolled patients with generalized sensory symptoms and pain after COVID-19 vaccination. Nine patients complaining of orthostatic intolerance also underwent cardiovascular autonomic tests.

Results: We found that all patients experienced widespread pain, and most of them (11 of 15) had a fibromyalgia syndrome. All patients had normal skin biopsy findings, and in the 9 patients with orthostatic intolerance, cardiovascular autonomic tests showed normal findings. Nevertheless, 5 patients had cold and warm detection abnormalities at the QST investigation.

Conclusions: In our study, most patients complaining of generalized sensory symptoms and pain after COVID-19 vaccination had clinical and diagnostic test findings compatible with a fibromyalgia syndrome. Although the abnormal QST findings we found in 5 patients might be compatible with a small-fibre neuropathy, they should be cautiously interpreted given the psychophysical characteristics of this diagnostic test. Further larger controlled studies are needed to define precisely the association between small fibre damage and COVID-19 vaccination.

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来源期刊
Pain Reports
Pain Reports Medicine-Anesthesiology and Pain Medicine
CiteScore
7.50
自引率
2.10%
发文量
93
审稿时长
8 weeks
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