Jie Dong , Qingwu Du , Tian Zhang , Xi Chen , Wencheng Zhang , Yajun Chen , Yaqi Zeng , Chunlei Li , Yueying Li , Yujie Wang , Kun Wang , Qingsong Pang
{"title":"食管癌症新辅助同期放化疗中鼻肠管进食的优势：回顾性研究","authors":"Jie Dong , Qingwu Du , Tian Zhang , Xi Chen , Wencheng Zhang , Yajun Chen , Yaqi Zeng , Chunlei Li , Yueying Li , Yujie Wang , Kun Wang , Qingsong Pang","doi":"10.1016/j.radmp.2023.05.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To compare the effects of oral intake and nasogastric tube (NG) feeding on nutritional status, complications and survival during neoadjuvant chemoradiotherapy for esophageal squamous-cell carcinoma (ESCC) patients.</p></div><div><h3>Methods</h3><p>A total of 61 ESCC cases treated with neoadjuvant chemoradiotherapy from December 2018 to March 2020 were enrolled, including (38 in oral intake group, and 22 in NG feeding group. Disease characteristics and baseline nutritional markers were collected in both groups. Nutritional status, complication and completion rate of chemoradiotherapy in both groups were evaluated.</p></div><div><h3>Results</h3><p>Compared with the oral intake group, patients in the NG feeding group had a later T stage (<em>P</em> = 0.027) and clinical stage (<em>P</em> = 0.014). The levels of energy intake (<em>P</em> = 0.033), serum prealbumin (<em>P</em> < 0.001), albumin (<em>P</em> = 0.017) and hemoglobin (<em>P</em> = 0.015) before treatment in NG group were significantly lower than those in oral intake group. Furthermore, patient-generated subjective global assessment (PG-SGA) score (<em>P</em> = 0.016) and the levels of serum C-reactive protein (<em>P</em> = 0.014) of NG feeding group were significantly higher than those of oral intake group. However, at the end of treatment, PG-SGA scores were increased in oral intake group and decreased in NG feeding group. In addition, the NG feeding group had a lower incidence of grade ≥2 esophagitis (<em>P</em> = 0.037), and higher completion rate of chemotherapy compared with oral intake group (<em>P</em> = 0.034). Meanwhile, the proportion of parenteral nutrition (<em>P</em> = 0.008) and anti-inflammatory (<em>P</em> = 0.022) treatment in NG feeding group was significantly lower than that in oral intake group. Although patients in the NG feeding group had a worse prognosis, there were no statistically significant differences in overall survival (OS) and progression-free survival (PFS) between the two groups (<em>P</em> > 0.05).</p></div><div><h3>Conclusions</h3><p>As a safe and effective enteral nutrition approach to improving nutrition, nasogastric tube feeding could increase treatment completion rate and reduce the incidence of ≥ grade 2 esophagitis reaction during neoadjuvant chemoradiotherapy.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 2","pages":"Pages 98-103"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advantages of nasogastric tube feeding during neoadjuvant concurrent chemoradiotherapy for esophageal cancer: A retrospective study\",\"authors\":\"Jie Dong , Qingwu Du , Tian Zhang , Xi Chen , Wencheng Zhang , Yajun Chen , Yaqi Zeng , Chunlei Li , Yueying Li , Yujie Wang , Kun Wang , Qingsong Pang\",\"doi\":\"10.1016/j.radmp.2023.05.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To compare the effects of oral intake and nasogastric tube (NG) feeding on nutritional status, complications and survival during neoadjuvant chemoradiotherapy for esophageal squamous-cell carcinoma (ESCC) patients.</p></div><div><h3>Methods</h3><p>A total of 61 ESCC cases treated with neoadjuvant chemoradiotherapy from December 2018 to March 2020 were enrolled, including (38 in oral intake group, and 22 in NG feeding group. Disease characteristics and baseline nutritional markers were collected in both groups. Nutritional status, complication and completion rate of chemoradiotherapy in both groups were evaluated.</p></div><div><h3>Results</h3><p>Compared with the oral intake group, patients in the NG feeding group had a later T stage (<em>P</em> = 0.027) and clinical stage (<em>P</em> = 0.014). The levels of energy intake (<em>P</em> = 0.033), serum prealbumin (<em>P</em> < 0.001), albumin (<em>P</em> = 0.017) and hemoglobin (<em>P</em> = 0.015) before treatment in NG group were significantly lower than those in oral intake group. Furthermore, patient-generated subjective global assessment (PG-SGA) score (<em>P</em> = 0.016) and the levels of serum C-reactive protein (<em>P</em> = 0.014) of NG feeding group were significantly higher than those of oral intake group. However, at the end of treatment, PG-SGA scores were increased in oral intake group and decreased in NG feeding group. In addition, the NG feeding group had a lower incidence of grade ≥2 esophagitis (<em>P</em> = 0.037), and higher completion rate of chemotherapy compared with oral intake group (<em>P</em> = 0.034). Meanwhile, the proportion of parenteral nutrition (<em>P</em> = 0.008) and anti-inflammatory (<em>P</em> = 0.022) treatment in NG feeding group was significantly lower than that in oral intake group. Although patients in the NG feeding group had a worse prognosis, there were no statistically significant differences in overall survival (OS) and progression-free survival (PFS) between the two groups (<em>P</em> > 0.05).</p></div><div><h3>Conclusions</h3><p>As a safe and effective enteral nutrition approach to improving nutrition, nasogastric tube feeding could increase treatment completion rate and reduce the incidence of ≥ grade 2 esophagitis reaction during neoadjuvant chemoradiotherapy.</p></div>\",\"PeriodicalId\":34051,\"journal\":{\"name\":\"Radiation Medicine and Protection\",\"volume\":\"4 2\",\"pages\":\"Pages 98-103\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiation Medicine and Protection\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666555723000230\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Health Professions\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiation Medicine and Protection","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666555723000230","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Health Professions","Score":null,"Total":0}
Advantages of nasogastric tube feeding during neoadjuvant concurrent chemoradiotherapy for esophageal cancer: A retrospective study
Objective
To compare the effects of oral intake and nasogastric tube (NG) feeding on nutritional status, complications and survival during neoadjuvant chemoradiotherapy for esophageal squamous-cell carcinoma (ESCC) patients.
Methods
A total of 61 ESCC cases treated with neoadjuvant chemoradiotherapy from December 2018 to March 2020 were enrolled, including (38 in oral intake group, and 22 in NG feeding group. Disease characteristics and baseline nutritional markers were collected in both groups. Nutritional status, complication and completion rate of chemoradiotherapy in both groups were evaluated.
Results
Compared with the oral intake group, patients in the NG feeding group had a later T stage (P = 0.027) and clinical stage (P = 0.014). The levels of energy intake (P = 0.033), serum prealbumin (P < 0.001), albumin (P = 0.017) and hemoglobin (P = 0.015) before treatment in NG group were significantly lower than those in oral intake group. Furthermore, patient-generated subjective global assessment (PG-SGA) score (P = 0.016) and the levels of serum C-reactive protein (P = 0.014) of NG feeding group were significantly higher than those of oral intake group. However, at the end of treatment, PG-SGA scores were increased in oral intake group and decreased in NG feeding group. In addition, the NG feeding group had a lower incidence of grade ≥2 esophagitis (P = 0.037), and higher completion rate of chemotherapy compared with oral intake group (P = 0.034). Meanwhile, the proportion of parenteral nutrition (P = 0.008) and anti-inflammatory (P = 0.022) treatment in NG feeding group was significantly lower than that in oral intake group. Although patients in the NG feeding group had a worse prognosis, there were no statistically significant differences in overall survival (OS) and progression-free survival (PFS) between the two groups (P > 0.05).
Conclusions
As a safe and effective enteral nutrition approach to improving nutrition, nasogastric tube feeding could increase treatment completion rate and reduce the incidence of ≥ grade 2 esophagitis reaction during neoadjuvant chemoradiotherapy.
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