5-溴-1-(4-氯苯)- 1h -吲哚-2-羧胺类新型高效抗菌剂

IF 1.5 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2018-12-19 DOI:10.1515/hc-2018-0107

Y. Mane, Smita S. Patil, D. Biradar, B. Khade

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引用次数: 4

摘要

摘要以庆大霉素和环丙沙星为内标，合成了10种5-溴吲哚-2-甲酰胺，并对其进行了表征和抗菌活性评价。化合物7a–c、7g和7h表现出较高的抗菌活性，最小抑菌浓度（MIC）为0.35–1.25μg/mL。化合物7a-c对大肠杆菌和铜绿假单胞菌的抗菌活性高于标准品。

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5-Bromo-1-(4-chlorobenzyl)-1H-indole-2-carboxamides as new potent antibacterial agents

Abstract Ten 5-bromoindole-2-carboxamides were synthesized, characterized and evaluated for antibacterial activity against pathogenic Gram-negative bacteria Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Salmonella Typhi using gentamicin and ciprofloxacin as internal standards. Compounds 7a–c, 7g and 7h exhibit high antibacterial activity with a minimum inhibitory concentration (MIC) of 0.35–1.25 μg/mL. Compounds 7a–c exhibit antibacterial activities that are higher than those of the standards against E. coli and P. aeruginosa.

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.