褪黑素对多囊卵巢综合征妇女体外受精(IVF)的促进作用。

Chonnam medical journal Pub Date : 2023-09-01 Epub Date: 2023-09-25 DOI:10.4068/cmj.2023.59.3.188
Shamim Pilehvari, Mahnaz Yavangui, Elham Paknahad, Zahra Cheraghi, Marzieh Ghorbani
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引用次数: 0

摘要

多囊卵巢综合征(PCOS)是最严重的疾病之一,约有20%的育龄妇女受到影响,对这些妇女补充褪黑激素是有效的。然而,这一领域的人体研究特别局限于试管婴儿候选者。本临床试验研究的目的是评估褪黑素对多囊卵巢综合征患者体外受精(IVF)的影响。在这项临床试验研究中,共有320名多囊卵巢综合征患者被随机分配到干预组和对照组。干预组的患者(n=160)每天接受三次褪黑素和二甲双胍的联合治疗(分别为3 mg和500 mg)。对照组(n=160)在促性腺激素开始前的周期黄体期接受500 mg二甲双胍。比较两组的卵母细胞和胚胎质量、卵母细胞数量和妊娠结局。我们的研究表明,中期II卵母细胞的频率(69.9%对57.9%,p
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Boosting Effects of Melatonin on the In Vitro Fertilization (IVF) of Women with Polycystic Ovary Syndrome.

The Boosting Effects of Melatonin on the In Vitro Fertilization (IVF) of Women with Polycystic Ovary Syndrome.

The Boosting Effects of Melatonin on the In Vitro Fertilization (IVF) of Women with Polycystic Ovary Syndrome.

The Boosting Effects of Melatonin on the In Vitro Fertilization (IVF) of Women with Polycystic Ovary Syndrome.

Polycystic ovary syndrome (PCOS) is one of the most critical disorders, which affects approximately 20% of women of childbearing age and melatonin supplementation in these women can be effective. However, human studies in this area are particularly limited to IVF candidates. The aim of this clinical trial study was to evaluate the effect of melatonin on the in vitro fertilization (IVF) in PCOS involved women. In this clinical trial study, a total of 320 women with PCOS were randomly assigned to the intervention and control groups. Patients in the intervention group (n=160) received a combination of melatonin and metformin (3 mg and 500 mg, respectively) three times a day. The control group (n=160) received metformin 500 mg from the luteal phase of the cycle before the start of gonadotropin. Oocyte and embryo quality, number of oocytes, and pregnancy outcomes were compared in both groups. Our study revealed that the frequency of Metaphase II oocytes (69.9% vs. 57.9%, p<0.001) and the number of embryos of the top-quality (grade A) were higher in the group treated with melatonin (40.3% vs. 29.9%, p=0.001). The rate of clinical pregnancy and implantation were also higher in the intervention group. The odds of clinical pregnancy in the intervention group was 1.8 times (p=0.039). Moreover, oral melatonin supplementation was effective in patients with PCOS, who were candidates for IVF because of the increased quality of mature oocytes, top-quality embryos, and increased odds of clinical pregnancy.

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