健康人的心理社会压力引起的肠道通透性:证据是什么?

IF 4.3 2区 医学 Q1 NEUROSCIENCES
Danique La Torre , Lukas Van Oudenhove , Tim Vanuytsel , Kristin Verbeke
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引用次数: 0

摘要

肠道屏障功能受损可能对宿主有害,因为它可能会使管腔抗原和毒素转移到上皮下组织和血液中。反过来,这可能会引起局部和系统免疫反应,并导致病理的发展。体外和动物研究强烈表明,心理社会压力是通过肥大细胞依赖机制增加肠道通透性的因素之一。值得注意的是,研究未能得出明确的证据,证明压力和肠道通透性之间的关系也存在于(健康)人类中。在目前的综述中,我们讨论了应激诱导的肠道通透性变化的机制,以及影响这些变化的假设因素,这些因素可能解释了从体外和动物到人类研究的转化困难。由于人类研究与动物研究在施加压力和测量肠道通透性的程度上有很大不同,因此很难得出关于(健康)人类压力与肠道通透性之间存在关系的结论。未来的研究应该考虑到这些困难,有必要对评估肠道通透性的体内方法进行更多的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence?

Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence?

Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence?

An impaired intestinal barrier function can be detrimental to the host as it may allow the translocation of luminal antigens and toxins into the subepithelial tissue and bloodstream. In turn, this may cause local and systemic immune responses and lead to the development of pathologies. In vitro and animal studies strongly suggest that psychosocial stress is one of the factors that can increase intestinal permeability via mast-cell dependent mechanisms. Remarkably, studies have not been able to yield unequivocal evidence that such relation between stress and intestinal permeability also exists in (healthy) humans. In the current Review, we discuss the mechanisms that are involved in stress-induced intestinal permeability changes and postulate factors that influence these alterations and that may explain the translational difficulties from in vitro and animal to human studies. As human research differs highly from animal research in the extent to which stress can be applied and intestinal permeability can be measured, it remains difficult to draw conclusions about the presence of a relation between stress and intestinal permeability in (healthy) humans. Future studies should bear in mind these difficulties, and more research into in vivo methods to assess intestinal permeability are warranted.

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来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
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