肠道微生物群对最常见的神经退行性痴呆发展的影响以及益生菌对老年人的潜在影响:范围界定综述。

IF 1.6 3区 医学 Q3 GENETICS & HEREDITY
David Mateo, Montse Marquès, José L. Domingo, Margarita Torrente
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引用次数: 0

摘要

痴呆症是当今最大的公共卫生挑战之一。它的高度社会经济影响以及诊断和治疗方面的困难日益引起老龄化世界人口的关注。近年来,对肠道微生物群与不同神经认知障碍之间关系的研究引起了人们的极大兴趣。几项研究报告了肠道微生物群失调与某些类型的痴呆之间的关系。益生菌被认为可以恢复这些痴呆症的微生态失调并改善神经认知症状。基于这些先前的发现,对受最常见痴呆影响的人类肠道微生物群的现有科学证据,以及近年来在这些患者中进行的益生菌试验进行了综述。短链脂肪酸(SCFA)和其他细菌代谢产物浓度的降低似乎在阿尔茨海默病(AD)和帕金森病痴呆症(PDD)神经认知症状的发作中起着重要作用。促炎分类群丰度的增加可能与两者以及路易体痴呆症中更严重的临床症状密切相关。额颞叶痴呆行为变体中存在严重的信息缺失。此外,AD中肠道微生物群组成的地理差异也有报道。益生菌对AD和PDD有一些潜在的有益作用。然而,由于结果存在争议,显然有必要进行进一步调查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Influence of gut microbiota on the development of most prevalent neurodegenerative dementias and the potential effect of probiotics in elderly: A scoping review

Influence of gut microbiota on the development of most prevalent neurodegenerative dementias and the potential effect of probiotics in elderly: A scoping review

Dementia is one of today's greatest public health challenges. Its high socio-economic impact and difficulties in diagnosis and treatment are of increasing concern to an aging world population. In recent years, the study of the relationship between gut microbiota and different neurocognitive disorders has gained a considerable interest. Several studies have reported associations between gut microbiota dysbiosis and some types of dementia. Probiotics have been suggested to restore dysbiosis and to improve neurocognitive symptomatology in these dementias. Based on these previous findings, the available scientific evidence on the gut microbiota in humans affected by the most prevalent dementias, as well as the probiotic trials conducted in these patients in recent years, have been here reviewed. Decreased concentrations of short-chain fatty acids (SCFA) and other bacterial metabolites appear to play a major role in the onset of neurocognitive symptoms in Alzheimer disease (AD) and Parkinson disease dementia (PDD). Increased abundance of proinflammatory taxa could be closely related to the more severe clinical symptoms in both, as well as in Lewy Bodies dementia. Important lack of information was noted in Frontotemporal dementia behavioral variant. Moreover, geographical differences in the composition of the gut microbiota have been reported in AD. Some potential beneficial effects of probiotics in AD and PDD have been reported. However, due to the controversial results further investigations are clearly necessary.

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来源期刊
CiteScore
5.90
自引率
7.10%
发文量
40
审稿时长
4-8 weeks
期刊介绍: Neuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG) , provides a forum for experimental and clinical investigations of the genetic mechanisms underlying neurologic and psychiatric disorders. It is a resource for novel genetics studies of the heritable nature of psychiatric and other nervous system disorders, characterized at the molecular, cellular or behavior levels. Neuropsychiatric Genetics publishes eight times per year.
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