酮umpolung通过Pudovik加成/[1，2]-磷-布鲁克重排实现钯催化的烯丙基烷基化

IF 10.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Science China Chemistry Pub Date : 2023-09-11 DOI:10.1007/s11426-023-1744-2

Jian Zhang, Jia-Yi Su, Yang-Zi Liu, Hao Li, Quannan Wang, Wei-Ping Deng

引用次数: 0

摘要

通过Pudovik加成/[1，2]-磷-Brook重排与亚磷酸盐反应，开发了钯催化的烯丙基烷基化反应。该方案为以有效和经济的方式合成具有潜在生物活性的高烯丙醇膦酸酯提供了一种简单的方法。该级联反应在具有优异官能团相容性的温和条件下进行。此外，还对催化不对称形式进行了探索。

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Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement

Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement with phosphites has been developed. The protocol offers a straightforward method for the synthesis of potentially bioactive homoallylic alcohol phosphonates in an efficient and economical way. This cascade reaction proceeds under mild conditions with excellent functional group compatibility. Furthermore, the catalytic asymmetric version has also been explored.

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来源期刊

Science China Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

7.30%

发文量

3787

审稿时长

2.2 months

期刊介绍： Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field. Categories of articles include: Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry. Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies. Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.