癌症干细胞与癌症治疗:最新进展和未来展望。

Mudassir Khan, Mashal Naeem, Sana Aftab Chaudary, Affan Ahmed, Aftab Ahmed
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引用次数: 0

摘要

癌症干细胞(CSCs)在肿瘤进展和转移中起着重要作用。这些细胞具有独特的自我更新和分化为特定组织细胞类型的能力。它们的自我更新能力使CSC能够持续一段时间,从而导致癌症复发和治疗耐药性。因此,靶向CSCs已成为一种很有前途的癌症治疗策略。CSC表现出分化、自我更新和可塑性,它们与恶性肿瘤的多个方面有关,如复发、转移、异质性、多药耐药性和辐射耐药性。虽然传统治疗主要针对非CSC的癌症细胞,但CSC经常存活,导致肿瘤复发和复发。本文着重于开发新的治疗策略,将常规治疗与CSC抑制剂相结合,以根除癌症细胞和CSC,从而治疗癌症并预防其复发。然而,CSC的多样性对CSC靶向疗法的发展构成了重大障碍,需要进行广泛的研究,以更好地理解和探索治疗方法。CSC靶向治疗的未来发展将在很大程度上依赖于克服这一障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cancer Stem Cells and Treatment of Cancer: An Update and Future Perspectives.

Cancer stem cells (CSCs) play an essential role in tumour progression and metastasis. Stem cell ability of self-renewal enables it to persist over time, thereby contributing to cancer relapse or recurrence and also resistance to current therapies. Therefore, targeting CSCs emerged as a promising strategy of cancer treatment. CSCs exhibit differentiation, self-renewal, and plasticity, they contribute to formation of malignant tumours, also favors, metastasis, heterogeneity, multidrug resistance, and radiation resistance. Coventional cancer treatments predominantly target cancer cells that are not CSCs, CSCs frequently survive, eventually leading to relapse. This article focuses on the development of novel therapeutic strategies that combine conventional treatments and CSC inhibitors to eradicate cancer cells and CSCs, for the better and permanent treatment. However, the diversity of CSCs is a significant obstacle in the development of CSC-targeted therapies, necessitating extensive research for a better understanding and exploration of therapeutic approaches. Future development of CSC-targeted therapies will rely heavily on overcoming this obstacle.

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