K同源型剪接调节蛋白：癌症和免疫疾病的作用机制。

IF 1.5 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2024-01-01 DOI:10.1615/CritRevEukaryotGeneExpr.2023048085

Jonathan D Leavenworth, Nabiha Yusuf, Quamarul Hassan

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引用次数: 0

摘要

K同源型剪接调节蛋白（KSRP）正在成为癌症生物学和免疫学的关键角色。作为一种单链核酸结合蛋白，它在转录和转录后调控中发挥作用，同时促进RNA代谢的多个阶段，以影响增殖和控制细胞命运。然而，它必须与其他蛋白质相互作用，才能决定其结合底物的命运。在这里，我们对这种重要的调节蛋白进行了简要综述，并描述了其影响RNA代谢、稳定性、miRNA生物发生和成熟、应激颗粒功能、转移和炎症过程的复杂亚细胞功能。

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K-Homology Type Splicing Regulatory Protein: Mechanism of Action in Cancer and Immune Disorders.

K homology-type splicing regulatory protein (KSRP) is emerging as a key player in cancer biology, and immunology. As a single-strand nucleic acid binding protein it functions in both transcriptional and post-transcriptional regulation, while facilitating multiple stages of RNA metabolism to affect proliferation and control cell fate. However, it must interact with other proteins to determine the fate of its bound substrate. Here we provide an minireview of this important regulatory protein and describe its complex subcellular functions to affect RNA metabolism, stability, miRNA biogenesis and maturation, stress granule function, metastasis, and inflammatory processes.

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来源期刊

Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.