槲皮素对骨稳态的调节作用:研究进展和未来展望。

The American journal of Chinese medicine Pub Date : 2023-01-01 Epub Date: 2023-10-09 DOI:10.1142/S0192415X23500891
Yujiang Xi, Jiayan Shen, Xiahuang Li, Yi Bao, Ting Zhao, Bo Li, Xiaoyu Zhang, Jian Wang, Yanyuan Bao, Jiamei Gao, Zhaohu Xie, Qi Wang, Qiu Luo, Hongling Shi, Zhaofu Li, Dongdong Qin
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引用次数: 0

摘要

在人口老龄化的背景下,骨稳态失衡已成为一个主要的公共医疗问题,这与骨质疏松、骨关节炎和骨折的发生密切相关。目前,用于临床治疗骨稳态失衡的大多数药物是双磷酸盐、降钙素、雌激素受体调节剂和抑制骨吸收的生物制剂或促进骨形成的甲状旁腺激素类似物。然而,也有许多不良反应。因此,有必要探索潜在的药物。槲皮素作为一种具有多种生物活性的黄酮醇化合物,广泛分布于植物中。研究发现,槲皮素可以通过多种途径和靶点调节骨稳态。深入探讨槲皮素的药理作用机制,对开发新药具有重要意义。这篇综述讨论了槲皮素对骨稳态的治疗机制,如调节长非编码RNA的表达、骨代谢的信号通路、各种类型的程序性细胞死亡、骨营养物质供应通路、抗氧化应激、抗炎和Sirtuins的激活。我们还总结了近年来在提高槲皮素生物利用度方面的进展,并提出了一些值得注意的问题,这可能有助于指导未来的研究工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regulatory Effects of Quercetin on Bone Homeostasis: Research Updates and Future Perspectives.

The imbalance of bone homeostasis has become a major public medical problem amid the background of an aging population, which is closely related to the occurrence of osteoporosis, osteoarthritis, and fractures. Presently, most drugs used in the clinical treatment of bone homeostasis imbalance are bisphosphonates, calcitonin, estrogen receptor modulators, and biological agents that inhibit bone resorption or parathyroid hormone analogs that promote bone formation. However, there are many adverse reactions. Therefore, it is necessary to explore potential drugs. Quercetin, as a flavonol compound with various biological activities, is widely distributed in plants. Studies have found that quercetin can regulate bone homeostasis through multiple pathways and targets. An in-depth exploration of the pharmacological mechanism of quercetin is of great significance for the development of new drugs. This review discusses the therapeutic mechanisms of quercetin on bone homeostasis, such as regulating the expression of long non-coding RNA, signaling pathways of bone metabolism, various types of programmed cell death, bone nutrients supply pathways, anti-oxidative stress, anti-inflammation, and activation of Sirtuins. We also summarize recent progress in improving quercetin bioavailability and propose some issues worth paying attention to, which may help guide future research efforts.

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