斑点氢呼气试验预测腹胀患者对低发酵低聚、二糖、单糖和多元醇饮食建议的反应。

IF 3.3 3区 医学 Q2 CLINICAL NEUROLOGY
Pochara Somvanapanich, Panyavee Pitisuttithum, Jarongkorn Sirimongkolkasem, Pakkapon Rattanachaisit, Sureeporn Jangsirikul, Tanisa Patcharatrakul, Sutep Gonlachanvit
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引用次数: 0

摘要

背景/目的:餐后肠道气体的增加在腹胀症状中起作用。我们的目的是研究点呼吸氢(H2)水平在预测对低发酵低聚、二糖、单糖和多元醇(FODMAPs)饮食的反应中的效用。方法:前瞻性纳入根据罗马IV标准诊断的功能性胃肠道疾病患者,伴有令人烦恼的腹胀>6个月。患者完成了7天的食物日记,并在基线时的常规午餐后2小时和营养师提出低FODMAP饮食建议后4周收集了呼吸样本。应答者被定义为在第四周腹胀得分改善≥30%。结果:38名患者(32名女性,52.6±13.8岁;22名肠易激综合征患者)完成了研究。21名患者(55%)被归类为应答者。有应答者和无应答者的基线总体胃肠道症状、腹胀、腹痛评分和高FODMAP项目数量相似。两组在随访中均显著降低了FODMAP高项目的摄入量,且数量相似。使用基线H2水平预测低FODMAPs响应性的曲线下面积为0.692(95%CI为0.51-0.86;P<0.05),最佳临界值为百万分之8(敏感性66.7%,特异性82.4%)。66%的应答者的基线H2水平>百万分之八,而无应答者的17%(P<0.05)。应答者的基准点氢水平为9.5(3.3-17.3),无应答者为4.5(3.3-6.3)(P<0.05)FODMAPs饮食建议。午餐后的现场呼吸测试,一种简单的护理点测试,可能有助于治疗腹胀患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Spot Hydrogen Breath Test for Predicting Response to Low Fermentable Oligo-, Di-, Mono-saccharides, and Polyols Dietary Advice in Patients With Bloating.

Background/aims: An increase in postprandial intestinal gas plays a role in bloating symptoms. We aim to study the utility of spot breath hydrogen (H2) level in predicting the response to a low fermentable oligo-, di-, mono-saccharides, and polyols (FODMAPs) diet.

Methods: Patients with functional gastrointestinal disorders diagnosed by Rome IV criteria with bothersome bloating for > 6 months were prospectively enrolled. Patients completed 7-day food diaries and collected a breath sample 2 hours after their usual lunch at baseline and 4 weeks after low FODMAPs dietary advice by a dietitian. The responder was defined as an improvement of ≥ 30% bloating scores in the fourth week.

Results: Thirty-eight patients (32 female, 52.6 ± 13.8 years; 22 irritable bowel syndrome) completed the study. Twenty-one patients (55%) were classified as responders. Baseline global gastrointestinal symptoms, bloating, abdominal pain scores, and numbers of high FODMAPs items were similar between responders and non-responders. Both groups significantly decreased high FODMAPs items intake with similar numbers at the follow-up. The area under the curve for predicting low FODMAPs responsiveness using baseline H2 levels was 0.692 (95%CI, 0.51-0.86; P < 0.05), with the best cutoff at 8 parts per million (sensitivity 66.7%, specificity 82.4%). 66% of responders had baseline H2 level > 8 parts per million vs 17% of non-responders (P < 0.05). The baseline spot hydrogen level in responders was 9.5 (3.3-17.3) vs 4.5 (3.3-6.3) in non-responders (P < 0.05).

Conclusions: A higher baseline breath hydrogen level was associated with bloating improvement after low FODMAPs dietary advice. A spot breath test after lunch, a simple point-of-care test, is possibly helpful in managing patients with bloating.

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来源期刊
Journal of Neurogastroenterology and Motility
Journal of Neurogastroenterology and Motility GASTROENTEROLOGY & HEPATOLOGY-CLINICAL NEUROLOGY
CiteScore
6.30
自引率
8.80%
发文量
96
期刊介绍: Journal of Neurogastroenterology and Motility (J Neurogastroenterol Motil) is a joint official journal of the Korean Society of Neurogastroenterology and Motility, the Thai Neurogastroenterology and Motility Society, the Japanese Society of Neurogastroenterology and Motility, the Indian Motility and Functional Disease Association, the Chinese Society of Gastrointestinal Motility, the South East Asia Gastro-Neuro Motility Association, the Taiwan Neurogastroenterology and Motility Society and the Asian Neurogastroenterology and Motility Association, launched in January 2010 after the title change from the Korean Journal of Neurogastroenterology and Motility, published from 1994 to 2009.
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