斑点氢呼气试验预测腹胀患者对低发酵低聚、二糖、单糖和多元醇饮食建议的反应。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Pochara Somvanapanich, Panyavee Pitisuttithum, Jarongkorn Sirimongkolkasem, Pakkapon Rattanachaisit, Sureeporn Jangsirikul, Tanisa Patcharatrakul, Sutep Gonlachanvit
{"title":"斑点氢呼气试验预测腹胀患者对低发酵低聚、二糖、单糖和多元醇饮食建议的反应。","authors":"Pochara Somvanapanich,&nbsp;Panyavee Pitisuttithum,&nbsp;Jarongkorn Sirimongkolkasem,&nbsp;Pakkapon Rattanachaisit,&nbsp;Sureeporn Jangsirikul,&nbsp;Tanisa Patcharatrakul,&nbsp;Sutep Gonlachanvit","doi":"10.5056/jnm22214","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aims: </strong>An increase in postprandial intestinal gas plays a role in bloating symptoms. We aim to study the utility of spot breath hydrogen (H<sub>2</sub>) level in predicting the response to a low fermentable oligo-, di-, mono-saccharides, and polyols (FODMAPs) diet.</p><p><strong>Methods: </strong>Patients with functional gastrointestinal disorders diagnosed by Rome IV criteria with bothersome bloating for > 6 months were prospectively enrolled. Patients completed 7-day food diaries and collected a breath sample 2 hours after their usual lunch at baseline and 4 weeks after low FODMAPs dietary advice by a dietitian. The responder was defined as an improvement of ≥ 30% bloating scores in the fourth week.</p><p><strong>Results: </strong>Thirty-eight patients (32 female, 52.6 ± 13.8 years; 22 irritable bowel syndrome) completed the study. Twenty-one patients (55%) were classified as responders. Baseline global gastrointestinal symptoms, bloating, abdominal pain scores, and numbers of high FODMAPs items were similar between responders and non-responders. Both groups significantly decreased high FODMAPs items intake with similar numbers at the follow-up. The area under the curve for predicting low FODMAPs responsiveness using baseline H<sub>2</sub> levels was 0.692 (95%CI, 0.51-0.86; <i>P</i> < 0.05), with the best cutoff at 8 parts per million (sensitivity 66.7%, specificity 82.4%). 66% of responders had baseline H<sub>2</sub> level > 8 parts per million vs 17% of non-responders (<i>P</i> < 0.05). The baseline spot hydrogen level in responders was 9.5 (3.3-17.3) vs 4.5 (3.3-6.3) in non-responders (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>A higher baseline breath hydrogen level was associated with bloating improvement after low FODMAPs dietary advice. A spot breath test after lunch, a simple point-of-care test, is possibly helpful in managing patients with bloating.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577458/pdf/","citationCount":"0","resultStr":"{\"title\":\"Spot Hydrogen Breath Test for Predicting Response to Low Fermentable Oligo-, Di-, Mono-saccharides, and Polyols Dietary Advice in Patients With Bloating.\",\"authors\":\"Pochara Somvanapanich,&nbsp;Panyavee Pitisuttithum,&nbsp;Jarongkorn Sirimongkolkasem,&nbsp;Pakkapon Rattanachaisit,&nbsp;Sureeporn Jangsirikul,&nbsp;Tanisa Patcharatrakul,&nbsp;Sutep Gonlachanvit\",\"doi\":\"10.5056/jnm22214\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/aims: </strong>An increase in postprandial intestinal gas plays a role in bloating symptoms. We aim to study the utility of spot breath hydrogen (H<sub>2</sub>) level in predicting the response to a low fermentable oligo-, di-, mono-saccharides, and polyols (FODMAPs) diet.</p><p><strong>Methods: </strong>Patients with functional gastrointestinal disorders diagnosed by Rome IV criteria with bothersome bloating for > 6 months were prospectively enrolled. Patients completed 7-day food diaries and collected a breath sample 2 hours after their usual lunch at baseline and 4 weeks after low FODMAPs dietary advice by a dietitian. The responder was defined as an improvement of ≥ 30% bloating scores in the fourth week.</p><p><strong>Results: </strong>Thirty-eight patients (32 female, 52.6 ± 13.8 years; 22 irritable bowel syndrome) completed the study. Twenty-one patients (55%) were classified as responders. Baseline global gastrointestinal symptoms, bloating, abdominal pain scores, and numbers of high FODMAPs items were similar between responders and non-responders. Both groups significantly decreased high FODMAPs items intake with similar numbers at the follow-up. The area under the curve for predicting low FODMAPs responsiveness using baseline H<sub>2</sub> levels was 0.692 (95%CI, 0.51-0.86; <i>P</i> < 0.05), with the best cutoff at 8 parts per million (sensitivity 66.7%, specificity 82.4%). 66% of responders had baseline H<sub>2</sub> level > 8 parts per million vs 17% of non-responders (<i>P</i> < 0.05). The baseline spot hydrogen level in responders was 9.5 (3.3-17.3) vs 4.5 (3.3-6.3) in non-responders (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>A higher baseline breath hydrogen level was associated with bloating improvement after low FODMAPs dietary advice. A spot breath test after lunch, a simple point-of-care test, is possibly helpful in managing patients with bloating.</p>\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2023-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577458/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5056/jnm22214\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5056/jnm22214","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0

摘要

背景/目的:餐后肠道气体的增加在腹胀症状中起作用。我们的目的是研究点呼吸氢(H2)水平在预测对低发酵低聚、二糖、单糖和多元醇(FODMAPs)饮食的反应中的效用。方法:前瞻性纳入根据罗马IV标准诊断的功能性胃肠道疾病患者,伴有令人烦恼的腹胀>6个月。患者完成了7天的食物日记,并在基线时的常规午餐后2小时和营养师提出低FODMAP饮食建议后4周收集了呼吸样本。应答者被定义为在第四周腹胀得分改善≥30%。结果:38名患者(32名女性,52.6±13.8岁;22名肠易激综合征患者)完成了研究。21名患者(55%)被归类为应答者。有应答者和无应答者的基线总体胃肠道症状、腹胀、腹痛评分和高FODMAP项目数量相似。两组在随访中均显著降低了FODMAP高项目的摄入量,且数量相似。使用基线H2水平预测低FODMAPs响应性的曲线下面积为0.692(95%CI为0.51-0.86;P<0.05),最佳临界值为百万分之8(敏感性66.7%,特异性82.4%)。66%的应答者的基线H2水平>百万分之八,而无应答者的17%(P<0.05)。应答者的基准点氢水平为9.5(3.3-17.3),无应答者为4.5(3.3-6.3)(P<0.05)FODMAPs饮食建议。午餐后的现场呼吸测试,一种简单的护理点测试,可能有助于治疗腹胀患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Spot Hydrogen Breath Test for Predicting Response to Low Fermentable Oligo-, Di-, Mono-saccharides, and Polyols Dietary Advice in Patients With Bloating.

Background/aims: An increase in postprandial intestinal gas plays a role in bloating symptoms. We aim to study the utility of spot breath hydrogen (H2) level in predicting the response to a low fermentable oligo-, di-, mono-saccharides, and polyols (FODMAPs) diet.

Methods: Patients with functional gastrointestinal disorders diagnosed by Rome IV criteria with bothersome bloating for > 6 months were prospectively enrolled. Patients completed 7-day food diaries and collected a breath sample 2 hours after their usual lunch at baseline and 4 weeks after low FODMAPs dietary advice by a dietitian. The responder was defined as an improvement of ≥ 30% bloating scores in the fourth week.

Results: Thirty-eight patients (32 female, 52.6 ± 13.8 years; 22 irritable bowel syndrome) completed the study. Twenty-one patients (55%) were classified as responders. Baseline global gastrointestinal symptoms, bloating, abdominal pain scores, and numbers of high FODMAPs items were similar between responders and non-responders. Both groups significantly decreased high FODMAPs items intake with similar numbers at the follow-up. The area under the curve for predicting low FODMAPs responsiveness using baseline H2 levels was 0.692 (95%CI, 0.51-0.86; P < 0.05), with the best cutoff at 8 parts per million (sensitivity 66.7%, specificity 82.4%). 66% of responders had baseline H2 level > 8 parts per million vs 17% of non-responders (P < 0.05). The baseline spot hydrogen level in responders was 9.5 (3.3-17.3) vs 4.5 (3.3-6.3) in non-responders (P < 0.05).

Conclusions: A higher baseline breath hydrogen level was associated with bloating improvement after low FODMAPs dietary advice. A spot breath test after lunch, a simple point-of-care test, is possibly helpful in managing patients with bloating.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信