解读食管失弛缓症的免疫复杂性。

IF 3.3 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurogastroenterology and Motility Pub Date : 2023-10-30 DOI:10.5056/jnm23141

Hyunsoo Chung

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Deciphering the Immune Complexity of Esophageal Achalasia.

infiltration is a known characteristic of EA, with eosinophils accumulating in the lower esophageal sphincter. Surprisingly, this study revealed a reduction in peripheral eosinophil counts in EA patients, particularly in those with severe symptoms. This discrepancy between local and systemic eosinophil levels suggests a complex relationship between tissue-specific immune responses and peripheral immune regulation. To gain further insights into the molecular mechanisms underlying EA, the researchers conducted RNA sequencing of peripheral blood mono-nuclear cells. This analysis identified 170 differentially expressed genes (DEGs) associated with EA. These DEGs were linked to various immune-related processes, including humoral immune responses, lymphocyte-mediated immunity, and complement activa-JNM

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来源期刊

Journal of Neurogastroenterology and Motility GASTROENTEROLOGY & HEPATOLOGY-CLINICAL NEUROLOGY

CiteScore

6.30

自引率

8.80%

发文量

期刊介绍： Journal of Neurogastroenterology and Motility (J Neurogastroenterol Motil) is a joint official journal of the Korean Society of Neurogastroenterology and Motility, the Thai Neurogastroenterology and Motility Society, the Japanese Society of Neurogastroenterology and Motility, the Indian Motility and Functional Disease Association, the Chinese Society of Gastrointestinal Motility, the South East Asia Gastro-Neuro Motility Association, the Taiwan Neurogastroenterology and Motility Society and the Asian Neurogastroenterology and Motility Association, launched in January 2010 after the title change from the Korean Journal of Neurogastroenterology and Motility, published from 1994 to 2009.