患有先天性梅毒的极早产儿的细胞因子谱。

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL

Fukushima Journal of Medical Science Pub Date : 2023-11-15 Epub Date: 2023-09-28 DOI:10.5387/fms.2023-06

Eisuke Fukama, Tomoaki Nomura, Daisuke Hatanaka, Michiko Kusakari, Hidehiro Takahashi, Toshihiko Nakamura, Naoto Takahashi

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引用次数: 0

摘要

我们报告了第一例先天性梅毒婴儿的细胞因子谱。这名女婴是在母亲接受梅毒治疗期间通过阴道分娩出生的，胎龄27周。辅助性T细胞（Th）-1细胞因子（白细胞介素（IL）-2，IL-12）和IL-17的升高支持Th-1的免疫机制，与成人梅毒病例相似。IL-6和粒细胞集落刺激因子（G-CSF）的协同作用也会引起类白血病反应。成人神经梅毒患者脑脊液中干扰素-γ和IL-17水平升高，但略有升高。

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Cytokine profiles in an extremely preterm infant with congenital syphilis.

We report the cytokine profiles of an infant with congenital syphilis as a first case. This female infant was born by vaginal delivery at a gestational age of 27 weeks during her mother's treatment for syphilis. Elevation of T helper (Th)-1 cytokines (interleukin (IL)-2, IL-12) and IL-17, which supports immunological mechanisms of Th-1, was similar to that in cases of syphilis in adults. IL-6 and granulocyte colony-stimulating factor (G-CSF), the synergistic effects of which cause the leukemoid reaction, were also elevated. The levels of interferon-γ and IL-17 in cerebral spinal fluid, which are elevated in neurosyphilis in adults, were slightly elevated.

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来源期刊

Fukushima Journal of Medical Science MEDICINE, GENERAL & INTERNAL-

CiteScore

1.70

自引率

12.50%

发文量