中心性肺栓塞患者肺梗死的临床预测因素和预后。

Expert review of respiratory medicine Pub Date : 2023-07-01 Epub Date: 2023-10-27 DOI:10.1080/17476348.2023.2263359
Jose Manuel Martinez Manzano, Kevin Bryan Lo, Omar Cantu-Martinez, Long Nguyen, Brenda Chiang, Simone A Jarrett, Sahana Tito, Alexander Prendergast, Maria A Planchart Ferretto, Willy Roque, Ammaar Wattoo, Zurab Azmaiparashvili, Sadia Benzaquen
{"title":"中心性肺栓塞患者肺梗死的临床预测因素和预后。","authors":"Jose Manuel Martinez Manzano,&nbsp;Kevin Bryan Lo,&nbsp;Omar Cantu-Martinez,&nbsp;Long Nguyen,&nbsp;Brenda Chiang,&nbsp;Simone A Jarrett,&nbsp;Sahana Tito,&nbsp;Alexander Prendergast,&nbsp;Maria A Planchart Ferretto,&nbsp;Willy Roque,&nbsp;Ammaar Wattoo,&nbsp;Zurab Azmaiparashvili,&nbsp;Sadia Benzaquen","doi":"10.1080/17476348.2023.2263359","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Given the heterogeneity of predisposing factors associated with pulmonary infarction (PI) and the lack of clinically relevant outcomes among patients with acute pulmonary embolism (PE) complicated by PI, further investigation is required.</p><p><strong>Methods: </strong>Retrospective study of patients with central PE in an 11-year period. Data were stratified according to the diagnosis of PI. Multivariable logistic regression analysis was used to analyze factors associated with PI development and determine if PI was associated with severe hypoxemic respiratory failure and mechanical ventilation use.</p><p><strong>Results: </strong>Of 645 patients with central PE, 24% (<i>n</i> = 156) had PI. After adjusting for demographics, comorbidities, and clinical features on admission, only age (OR 0.98, CI 0.96-0.99; <i>p</i> = 0.008) was independently associated with PI. Regarding outcomes, 35% (<i>n</i> = 55) had severe hypoxemic respiratory failure, and 19% (<i>n</i> = 29) required mechanical ventilation. After adjusting for demographics, PE severity, and right ventricular dysfunction, PI was independently associated with severe hypoxemic respiratory failure (OR 1.78; CI 1.18-2.69, <i>p</i> = 0.005) and mechanical ventilation (OR 1.92; CI 1.14-3.22, <i>p</i> = 0.013).</p><p><strong>Conclusions: </strong>Aging is a protective factor against PI. In acute central PE, subjects with PI had higher odds of developing severe hypoxemic respiratory failure and requiring mechanical ventilation.</p>","PeriodicalId":94007,"journal":{"name":"Expert review of respiratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical predictors and outcomes of pulmonary infarction in patients with central pulmonary embolism.\",\"authors\":\"Jose Manuel Martinez Manzano,&nbsp;Kevin Bryan Lo,&nbsp;Omar Cantu-Martinez,&nbsp;Long Nguyen,&nbsp;Brenda Chiang,&nbsp;Simone A Jarrett,&nbsp;Sahana Tito,&nbsp;Alexander Prendergast,&nbsp;Maria A Planchart Ferretto,&nbsp;Willy Roque,&nbsp;Ammaar Wattoo,&nbsp;Zurab Azmaiparashvili,&nbsp;Sadia Benzaquen\",\"doi\":\"10.1080/17476348.2023.2263359\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Given the heterogeneity of predisposing factors associated with pulmonary infarction (PI) and the lack of clinically relevant outcomes among patients with acute pulmonary embolism (PE) complicated by PI, further investigation is required.</p><p><strong>Methods: </strong>Retrospective study of patients with central PE in an 11-year period. Data were stratified according to the diagnosis of PI. Multivariable logistic regression analysis was used to analyze factors associated with PI development and determine if PI was associated with severe hypoxemic respiratory failure and mechanical ventilation use.</p><p><strong>Results: </strong>Of 645 patients with central PE, 24% (<i>n</i> = 156) had PI. After adjusting for demographics, comorbidities, and clinical features on admission, only age (OR 0.98, CI 0.96-0.99; <i>p</i> = 0.008) was independently associated with PI. Regarding outcomes, 35% (<i>n</i> = 55) had severe hypoxemic respiratory failure, and 19% (<i>n</i> = 29) required mechanical ventilation. After adjusting for demographics, PE severity, and right ventricular dysfunction, PI was independently associated with severe hypoxemic respiratory failure (OR 1.78; CI 1.18-2.69, <i>p</i> = 0.005) and mechanical ventilation (OR 1.92; CI 1.14-3.22, <i>p</i> = 0.013).</p><p><strong>Conclusions: </strong>Aging is a protective factor against PI. In acute central PE, subjects with PI had higher odds of developing severe hypoxemic respiratory failure and requiring mechanical ventilation.</p>\",\"PeriodicalId\":94007,\"journal\":{\"name\":\"Expert review of respiratory medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Expert review of respiratory medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/17476348.2023.2263359\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/10/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert review of respiratory medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/17476348.2023.2263359","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/27 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:鉴于与肺梗死(PI)相关的易感因素的异质性,以及急性肺栓塞(PE)并发PI患者缺乏临床相关结果,需要进一步研究。方法:对11年来中心性PE患者进行回顾性研究。根据PI的诊断对数据进行分层。多变量逻辑回归分析用于分析与PI发展相关的因素,并确定PI是否与严重低氧血症性呼吸衰竭和机械通气使用相关。结果:645例中枢性PE患者中,24%(n = 156)具有PI。在对人口统计学、合并症和入院时的临床特征进行调整后,只有年龄(OR 0.98,CI 0.96-0.99;p = 0.008)与PI独立相关。关于结果,35%(n = 55)有严重低氧性呼吸衰竭,19%(n = 29)需要机械通风。在校正人口统计学、PE严重程度和右心室功能障碍后,PI与严重低氧性呼吸衰竭独立相关(OR 1.78;CI 1.18-2.69,p = 0.005)和机械通气(OR 1.92;CI 1.14-3.22,p = 0.013)。结论:衰老是PI的保护因素。在急性中枢性PE中,PI受试者发生严重低氧性呼吸衰竭和需要机械通气的几率更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical predictors and outcomes of pulmonary infarction in patients with central pulmonary embolism.

Background: Given the heterogeneity of predisposing factors associated with pulmonary infarction (PI) and the lack of clinically relevant outcomes among patients with acute pulmonary embolism (PE) complicated by PI, further investigation is required.

Methods: Retrospective study of patients with central PE in an 11-year period. Data were stratified according to the diagnosis of PI. Multivariable logistic regression analysis was used to analyze factors associated with PI development and determine if PI was associated with severe hypoxemic respiratory failure and mechanical ventilation use.

Results: Of 645 patients with central PE, 24% (n = 156) had PI. After adjusting for demographics, comorbidities, and clinical features on admission, only age (OR 0.98, CI 0.96-0.99; p = 0.008) was independently associated with PI. Regarding outcomes, 35% (n = 55) had severe hypoxemic respiratory failure, and 19% (n = 29) required mechanical ventilation. After adjusting for demographics, PE severity, and right ventricular dysfunction, PI was independently associated with severe hypoxemic respiratory failure (OR 1.78; CI 1.18-2.69, p = 0.005) and mechanical ventilation (OR 1.92; CI 1.14-3.22, p = 0.013).

Conclusions: Aging is a protective factor against PI. In acute central PE, subjects with PI had higher odds of developing severe hypoxemic respiratory failure and requiring mechanical ventilation.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信