Pannexin-1通道、ATP和嘌呤能受体在HIV和严重急性呼吸系统综合征冠状病毒2型发病机制中的作用。

IF 4 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2023-09-19 DOI:10.1016/j.coph.2023.102404

Cristian A. Hernandez, Eliseo A. Eugenin

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引用次数: 0

摘要

人类免疫缺陷病毒-1（HIV）和严重急性呼吸综合征冠状病毒-2（严重急性呼吸系统综合征冠状病毒2）等传染源利用宿主蛋白在宿主内感染、复制和诱导炎症。这些疾病的一个关键组成部分是血管内皮素-1通道、细胞外ATP和嘌呤能受体之间的轴。在这里，我们描述了潘nexin-1/嘌呤能方法在预防或减少这些病原体的破坏性后果方面的潜在治疗作用。

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The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2

Infectious agents such as human immune deficiency virus-1 (HIV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and induce inflammation within the host. A critical component of these diseases is the axis between pannexin-1 channels, extracellular ATP, and purinergic receptors. Here, we describe the potential therapeutic role of Pannexin-1/purinergic approaches to prevent or reduce the devastating consequences of these pathogens.

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.