LIPL研究:慢性冠状动脉综合征患者餐后血脂、炎症和血小板活性。

IF 1.4 Q3 PERIPHERAL VASCULAR DISEASE
Edita Pogran , Paul M. Haller , Claudia Wegberger , Maximilian Tscharre , Irena Vujasin , Christoph C. Kaufmann , Petra Dick , Bernhard Jäger , Johann Wojta , Kurt Huber
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引用次数: 0

摘要

背景和目的:动脉粥样硬化的变化主要是在非禁食脂质的影响下发生的。到目前为止,餐后状态下的研究主要在健康受试者身上进行。这项探索性的横断面研究调查了餐后状态下不同心血管风险状况患者的脂质状况、炎症和血小板活化的变化。方法:研究人群包括66名具有不同心血管风险的患者:有慢性冠状动脉综合征(CCS)和2型糖尿病(DM2)病史的患者(n=20),无DM2病史的CCS患者(n=25),以及健康对照组(n=21)。在禁食状态期间以及标准化脂肪餐后3小时和5小时,使用标准化口服脂肪耐受测试(OFTT)(含90g脂肪的奶昔)评估脂质变量、血小板功能和炎症标志物。结果:CCS和DM2患者年龄明显较大,BMI最高。所有CCS患者均服用乙酰水杨酸,95%的CCS患者服用高剂量他汀类药物。与CCS受试者相比,对照组在OFTT期间的白细胞和中性粒细胞绝对计数显著增加。在OFTT期间,HDL显著降低,甘油三酯升高,但各组之间没有差异。各组间血小板活性变化无显著性差异。结论:与CCS±DM2相比,OFTT导致健康组餐后炎症反应增加,而脂质和血小板活性没有变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The LIPL study: Postprandial lipid profile, inflammation, and platelet activity in patients with chronic coronary syndrome

The LIPL study: Postprandial lipid profile, inflammation, and platelet activity in patients with chronic coronary syndrome

The LIPL study: Postprandial lipid profile, inflammation, and platelet activity in patients with chronic coronary syndrome

The LIPL study: Postprandial lipid profile, inflammation, and platelet activity in patients with chronic coronary syndrome

Background and aims

It is suggested that the changes in atherosclerosis happen mainly under the influence of non-fasting lipids. To date, the studies in the postprandial state were primarily performed on healthy subjects. This exploratory, cross-sectional study investigates the change in lipid profile, inflammation, and platelet activation in patients with different cardiovascular risk profiles in the postprandial state.

Methods

The studied population consists of 66 patients with different cardiovascular risks: patients with a history of the chronic coronary syndrome (CCS) and diabetes mellitus type 2 (DM2) (n = 20), CCS without DM2 (n = 25), and a healthy control group (n = 21). Lipid variables and markers of platelet function and inflammation were assessed during the fasting state and three and 5 h after a standardized fat meal using a standardized oral fat tolerance test (OFTT), a milkshake with 90 g of fat.

Results

Patients with CCS and DM2 were significantly older and had the highest BMI. All patients with CCS were on acetylsalicylic acid, and 95% of CCS patients were on high-dose statins. The absolute leukocyte and neutrophile count increased significantly in the control group during the OFTT in comparison to CCS subjects. There was a significant decrease of HDL and increase of triglycerides during the OFTT, however with no difference between groups. There was no difference in the change of platelet activity between all groups.

Conclusion

This study showed that OFTT leads to an increased postprandial inflammation response in healthy group compared to CCS ± DM2 while there was no change in lipid profile and platelet activity.

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来源期刊
Atherosclerosis plus
Atherosclerosis plus Cardiology and Cardiovascular Medicine
CiteScore
2.60
自引率
0.00%
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审稿时长
66 days
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