Rafael Boucher MD , Oscar Haigh PhD , Emmanuel Barreau MD , Stéphane Champiat MD, PhD , Olivier Lambotte MD, PhD , Clovis Adam MD , Marc Labetoulle MD, PhD , Antoine Rousseau MD, PhD
{"title":"与现代抗癌疗法相关的眼部表面毒性。","authors":"Rafael Boucher MD , Oscar Haigh PhD , Emmanuel Barreau MD , Stéphane Champiat MD, PhD , Olivier Lambotte MD, PhD , Clovis Adam MD , Marc Labetoulle MD, PhD , Antoine Rousseau MD, PhD","doi":"10.1016/j.survophthal.2023.10.002","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span><span>Cancer treatments have recently shifted from broad-spectrum </span>cytotoxic therapies to more focused treatments, maximizing anticancerous activity while reducing toxicity to healthy cells. These modern </span>anticancer therapies (MATs) encompass a wide range of innovative molecules that include </span>immune checkpoint inhibitors<span><span> and other targeted anticancer therapies, comprising antibody drug conjugates<span> and inhibitors of signal transduction. Some MATs are associated with </span></span>ocular surface<span> adverse events that can cause severe discomfort and even lead to loss of vision. While these complications remain rare, they are probably underreported. It is likely that both oncologists and ophthalmologists will come across MATs-associated ocular surface-adverse events in their practices, owing to the increasing number of patients being treated with MATs. Rapid identification of ocular surface-adverse events is crucial, as early intervention can manage these conditions to avoid vision loss and reduce negative impacts on </span></span></span>quality of life. We discuss characteristics of ocular surface pathologies attributed to MATs, describe the suspected underlying pathophysiological mechanisms, and outline the main lines of treatment.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ocular surface toxicities associated with modern anticancer therapies\",\"authors\":\"Rafael Boucher MD , Oscar Haigh PhD , Emmanuel Barreau MD , Stéphane Champiat MD, PhD , Olivier Lambotte MD, PhD , Clovis Adam MD , Marc Labetoulle MD, PhD , Antoine Rousseau MD, PhD\",\"doi\":\"10.1016/j.survophthal.2023.10.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span><span>Cancer treatments have recently shifted from broad-spectrum </span>cytotoxic therapies to more focused treatments, maximizing anticancerous activity while reducing toxicity to healthy cells. These modern </span>anticancer therapies (MATs) encompass a wide range of innovative molecules that include </span>immune checkpoint inhibitors<span><span> and other targeted anticancer therapies, comprising antibody drug conjugates<span> and inhibitors of signal transduction. Some MATs are associated with </span></span>ocular surface<span> adverse events that can cause severe discomfort and even lead to loss of vision. While these complications remain rare, they are probably underreported. It is likely that both oncologists and ophthalmologists will come across MATs-associated ocular surface-adverse events in their practices, owing to the increasing number of patients being treated with MATs. Rapid identification of ocular surface-adverse events is crucial, as early intervention can manage these conditions to avoid vision loss and reduce negative impacts on </span></span></span>quality of life. We discuss characteristics of ocular surface pathologies attributed to MATs, describe the suspected underlying pathophysiological mechanisms, and outline the main lines of treatment.</p></div>\",\"PeriodicalId\":22102,\"journal\":{\"name\":\"Survey of ophthalmology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.1000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Survey of ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0039625723001340\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Survey of ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0039625723001340","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Ocular surface toxicities associated with modern anticancer therapies
Cancer treatments have recently shifted from broad-spectrum cytotoxic therapies to more focused treatments, maximizing anticancerous activity while reducing toxicity to healthy cells. These modern anticancer therapies (MATs) encompass a wide range of innovative molecules that include immune checkpoint inhibitors and other targeted anticancer therapies, comprising antibody drug conjugates and inhibitors of signal transduction. Some MATs are associated with ocular surface adverse events that can cause severe discomfort and even lead to loss of vision. While these complications remain rare, they are probably underreported. It is likely that both oncologists and ophthalmologists will come across MATs-associated ocular surface-adverse events in their practices, owing to the increasing number of patients being treated with MATs. Rapid identification of ocular surface-adverse events is crucial, as early intervention can manage these conditions to avoid vision loss and reduce negative impacts on quality of life. We discuss characteristics of ocular surface pathologies attributed to MATs, describe the suspected underlying pathophysiological mechanisms, and outline the main lines of treatment.
期刊介绍:
Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.