细胞外微小RNA与减肥的关系——系统综述和荟萃分析。

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Camilla H B Veie, Isabella M T Nielsen, Nanna L S Frisk, Louise T Dalgaard
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引用次数: 0

摘要

肥胖是心血管疾病和2型糖尿病的重要危险因素。即使是5-15%的适度减肥也能改善代谢健康,但缺乏表明减肥效率的循环标志物。微小RNA是基因表达的小型非编码转录后调节因子,从组织分泌到循环中,可能是代谢健康的潜在生物标志物。然而,目前尚不清楚哪些特定的微小RNA物种的水平会因体重减轻而发生可复制的变化。在这项研究中,我们进行了一项系统综述和荟萃分析,通过比较干预驱动的减肥后的基线水平和随访水平,研究与减肥相关的微小RNA。本系统综述根据PRISMA指南进行,检索PubMed和SCOPUS。初步搜索共产生697篇文章,根据先前确定的纳入和排除标准进行筛选。在对文章进行筛选后,审查的基础是纳入27篇全文文章,对这些文章的质量和偏倚风险进行了评估。我们进行了系统的数据提取,然后计算miRNA的相对值。对三项或多项研究中研究的miRNA物种进行了荟萃分析:miR-26a、miR-126和miR-223在减肥后总体显著增加,而miR-142在减肥后显著减少。miR-221、miR-140、miR-122和miR-146在干预驱动的减肥中没有显著变化。这些结果表明,在减肥过程中,很少有miRNA发生显著变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Extracellular microRNAs in Relation to Weight Loss-A Systematic Review and Meta-Analysis.

Extracellular microRNAs in Relation to Weight Loss-A Systematic Review and Meta-Analysis.

Extracellular microRNAs in Relation to Weight Loss-A Systematic Review and Meta-Analysis.

Extracellular microRNAs in Relation to Weight Loss-A Systematic Review and Meta-Analysis.

Obesity is an important risk factor for cardiovascular disease and type 2 diabetes mellitus. Even a modest weight loss of 5-15% improves metabolic health, but circulating markers to indicate weight loss efficiency are lacking. MicroRNAs, small non-coding post-transcriptional regulators of gene expression, are secreted from tissues into the circulation and may be potential biomarkers for metabolic health. However, it is not known which specific microRNA species are reproducibly changed in levels by weight loss. In this study, we performed a systematic review and meta-analysis to investigate the microRNAs associated with weight loss by comparing baseline to follow-up levels following intervention-driven weight loss. This systematic review was performed according to the PRISMA guidelines with searches in PubMed and SCOPUS. The primary search resulted in a total of 697 articles, which were screened according to the prior established inclusion and exclusion criteria. Following the screening of articles, the review was based on the inclusion of 27 full-text articles, which were evaluated for quality and the risk of bias. We performed systematic data extraction, whereafter the relative values for miRNAs were calculated. A meta-analysis was performed for the miRNA species investigated in three or more studies: miR-26a, miR-126, and miR-223 were overall significantly increased following weight loss, while miR-142 was significantly decreased after weight loss. miR-221, miR-140, miR-122, and miR-146 were not significantly changed by intervention-driven weight loss. These results indicate that few miRNAs are significantly changed during weight loss.

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来源期刊
Non-Coding RNA
Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
6.70
自引率
4.70%
发文量
74
审稿时长
10 weeks
期刊介绍: Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.
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