中国缺血性脑卒中预后危险因素分析:一项多中心回顾性临床研究;中国全国调查。

Yuting Cao, Ying Chen, Xiaoli Zhang, Yongjun Wang
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引用次数: 1

摘要

背景:脑卒中是一种严重威胁人类健康的疾病,在中国和世界范围内都是如此。识别和确定其危险因素是干预和评估预后的先决条件。多年来,年龄、糖尿病和高血压等危险因素逐渐确立。然而,目前对性别对缺血性脑卒中预后的影响还没有达成共识。目的:我们的研究目的是基于第三次中国国家卒中登记[CNSR-II]的结果,分析性别与卒中后预后之间的相关性,以及可能因性别而混淆的其他危险因素对缺血性卒中的影响和潜在干预措施。方法:CNSR-III在2015年至2018年间招募了14146名急性缺血性脑卒中患者。我们的研究包括13972名患者,他们有完整的随访信息。这项研究分析了基本信息、社会经济状况、生活习惯、病史和卒中后预后。结果:在单因素分析中,性别与缺血性卒中的功能预后、卒中复发和全因死亡之间存在显著关系。男性脑卒中患者的预后比女性患者好。在多变量分析中,我们发现年龄、心房颤动、糖尿病、高血压和中风的严重程度对缺血性中风的预后有不利影响。在对其他危险因素进行校正后,女性患者在3个月时的功能预后比男性患者差[比值比[OR]1.16,95%置信区间[CI],1.025-1.314]。性别与3个月后中风复发无显著相关性[危险比[HR]1.141,95%CI,0.975-1.336]。此外,与男性患者相比,女性脑卒中患者在12个月时的累计死亡率较低[HR 0.777,95%CI,0.628-0.963]。结论:我们的研究确定了脑卒中相关残疾、复发和死亡的性别差异,并试图解释这些差异的原因。我们的研究清楚地表明,这种差异很大一部分可归因于年龄、社会经济因素、生活习惯和病史,而不是性别本身。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Analysis of Prognostic Risk Factors for Ischemic Stroke in China: A Multicentre Retrospective Clinical Study; A National Survey in China.

Analysis of Prognostic Risk Factors for Ischemic Stroke in China: A Multicentre Retrospective Clinical Study; A National Survey in China.

Analysis of Prognostic Risk Factors for Ischemic Stroke in China: A Multicentre Retrospective Clinical Study; A National Survey in China.

Analysis of Prognostic Risk Factors for Ischemic Stroke in China: A Multicentre Retrospective Clinical Study; A National Survey in China.

Background: Stroke is a serious disease that threatens human health both in China and worldwide. Identifying and establishing its risk factors are prerequisites for intervention and evaluation of prognosis. Over the years, risk factors, such as age, diabetes, and hypertension, have gradually been established. However, at present, there is no consensus on the influence of sex on the prognosis of ischaemic stroke.

Aims: The aims of our research was to analyse the correlation between sex and poststroke prognosis based on the results of the Third China National Stroke Registry [CNSR-III], as well as the influence of other risk factors that may be confounded by sex on ischaemic stroke and potential interventions.

Methods: The CNSR-III recruited 14146 acute ischaemic stroke [AIS] patients between 2015 and 2018. Our study included 13,972 patients who had complete follow-up information. This research analysed basic information, socioeconomic status, lifestyle habits, medical history, and poststroke prognosis.

Results: There was a conspicuous relationship between sex and functional prognosis, stroke recurrence and all-cause death due to ischemic stroke in univariate analysis. Male stroke patients had a better prognosis than female patients. In multivariate analysis, we found that age, atrial fibrillation [AF], diabetes, hypertension and the severity of stroke had adverse effects on ischemic stroke prognosis. After adjustment for other risk factors, the functional prognosis of female patients at 3 months was worse than that of male patients [odds ratio [OR] 1.16, 95% confidence interval [CI], 1.025- 1.314]. Sex had a nonsignificant association with stroke recurrence at 3 months [hazard ratio [HR] 1.141, 95% CI, 0.975-1.336]. Furthermore, compared to male patients, female stroke patients had a lower cumulative death rate at 12 months [HR 0.777, 95% CI, 0.628-0.963].

Conclusion: Our study identified sex differences in stroke-related disability, recurrence, and death and attempted to explain the causes of these differences. Our study clearly showed that a large proportion of this difference could be attributed to age, socioeconomic factors, lifestyle habits, and medical history, confounded by sex differences rather than sex per se.

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